View in EDS HTML Full Text PDF Full Text

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism.

Saved in:
Bibliographic Details
Title: mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism.
Authors: Levy T; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel., Voeltzke K; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany., Hruby L; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany., Alasad K; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel., Bas Z; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany., Snaebjörnsson M; Biochemistry and Molecular Biology, Theodor-Boveri-Institute, 97074, Würzburg, Germany.; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Marciano R; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel., Scharov K; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany., Planque M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium., Vriens K; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium., Christen S; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium., Funk CM; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ), 69120, Heidelberg, Germany., Hassiepen C; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany., Kahler A; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany., Heider B; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany., Picard D; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; German cancer consortium (DKTK) partner site Essen/Düsseldorf, 40225, Düsseldorf, Germany., Lim JKM; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany., Stefanski A; Molecular Proteomics Laboratory, Biomedical Research Center (BMFZ), Heinrich Heine University, Medical Faculty, Düsseldorf, Germany., Bendrin K; Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany., Vargas-Toscano A; Clinic for Neurosurgery, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; Experimental and Clinical Research Center, Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13125, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Radiation Oncology, 13353, Berlin, Germany., Kahlert UD; Molecular and Experimental Surgery, University Clinic for General-, Visceral, Vascular- and Transplantation Surgery, Faculty of Medicine and University Medicine, Otto-von-Guericke-University, 39120, Magdeburg, Germany., Stühler K; Molecular Proteomics Laboratory, Biomedical Research Center (BMFZ), Heinrich Heine University, Medical Faculty, Düsseldorf, Germany., Remke M; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; German cancer consortium (DKTK) partner site Essen/Düsseldorf, 40225, Düsseldorf, Germany., Elkabets M; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Science, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel., Grünewald TGP; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ), 69120, Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Reichert AS; Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany., Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium., Schulze A; Biochemistry and Molecular Biology, Theodor-Boveri-Institute, 97074, Würzburg, Germany.; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Reifenberger G; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; German cancer consortium (DKTK) partner site Essen/Düsseldorf, 40225, Düsseldorf, Germany., Rotblat B; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel. rotblat@bgu.ac.il.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel. rotblat@bgu.ac.il., Leprivier G; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany. gabriel.leprivier@med.uni-duesseldorf.de.
Source: Nature communications [Nat Commun] 2024 May 14; Vol. 15 (1), pp. 4083. Date of Electronic Publication: 2024 May 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 38744825
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Levy+T%22">Levy T</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.<br /><searchLink fieldCode="AU" term="%22Voeltzke+K%22">Voeltzke K</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Hruby+L%22">Hruby L</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Alasad+K%22">Alasad K</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.<br /><searchLink fieldCode="AU" term="%22Bas+Z%22">Bas Z</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Snaebjörnsson+M%22">Snaebjörnsson M</searchLink>; Biochemistry and Molecular Biology, Theodor-Boveri-Institute, 97074, Würzburg, Germany.; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Marciano+R%22">Marciano R</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.<br /><searchLink fieldCode="AU" term="%22Scharov+K%22">Scharov K</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Planque+M%22">Planque M</searchLink>; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vriens+K%22">Vriens K</searchLink>; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Christen+S%22">Christen S</searchLink>; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Funk+CM%22">Funk CM</searchLink>; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ), 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hassiepen+C%22">Hassiepen C</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Kahler+A%22">Kahler A</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Heider+B%22">Heider B</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Picard+D%22">Picard D</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; German cancer consortium (DKTK) partner site Essen/Düsseldorf, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Lim+JKM%22">Lim JKM</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Stefanski+A%22">Stefanski A</searchLink>; Molecular Proteomics Laboratory, Biomedical Research Center (BMFZ), Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Bendrin+K%22">Bendrin K</searchLink>; Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Vargas-Toscano+A%22">Vargas-Toscano A</searchLink>; Clinic for Neurosurgery, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; Experimental and Clinical Research Center, Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13125, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Radiation Oncology, 13353, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kahlert+UD%22">Kahlert UD</searchLink>; Molecular and Experimental Surgery, University Clinic for General-, Visceral, Vascular- and Transplantation Surgery, Faculty of Medicine and University Medicine, Otto-von-Guericke-University, 39120, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Stühler+K%22">Stühler K</searchLink>; Molecular Proteomics Laboratory, Biomedical Research Center (BMFZ), Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Remke+M%22">Remke M</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; German cancer consortium (DKTK) partner site Essen/Düsseldorf, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Elkabets+M%22">Elkabets M</searchLink>; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Science, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.<br /><searchLink fieldCode="AU" term="%22Grünewald+TGP%22">Grünewald TGP</searchLink>; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ), 69120, Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Reichert+AS%22">Reichert AS</searchLink>; Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Fendt+SM%22">Fendt SM</searchLink>; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, 3000, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Schulze+A%22">Schulze A</searchLink>; Biochemistry and Molecular Biology, Theodor-Boveri-Institute, 97074, Würzburg, Germany.; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Reifenberger+G%22">Reifenberger G</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany.; German cancer consortium (DKTK) partner site Essen/Düsseldorf, 40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Rotblat+B%22">Rotblat B</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel. rotblat@bgu.ac.il.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel. rotblat@bgu.ac.il.<br /><searchLink fieldCode="AU" term="%22Leprivier+G%22">Leprivier G</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, 40225, Düsseldorf, Germany. gabriel.leprivier@med.uni-duesseldorf.de.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2024 May 14; Vol. 15 (1), pp. 4083. <i>Date of Electronic Publication: </i>2024 May 14.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=38744825
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-024-48386-y
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 4083
    Titles:
      – TitleFull: mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Levy T
      – PersonEntity:
          Name:
            NameFull: Voeltzke K
      – PersonEntity:
          Name:
            NameFull: Hruby L
      – PersonEntity:
          Name:
            NameFull: Alasad K
      – PersonEntity:
          Name:
            NameFull: Bas Z
      – PersonEntity:
          Name:
            NameFull: Snaebjörnsson M
      – PersonEntity:
          Name:
            NameFull: Marciano R
      – PersonEntity:
          Name:
            NameFull: Scharov K
      – PersonEntity:
          Name:
            NameFull: Planque M
      – PersonEntity:
          Name:
            NameFull: Vriens K
      – PersonEntity:
          Name:
            NameFull: Christen S
      – PersonEntity:
          Name:
            NameFull: Funk CM
      – PersonEntity:
          Name:
            NameFull: Hassiepen C
      – PersonEntity:
          Name:
            NameFull: Kahler A
      – PersonEntity:
          Name:
            NameFull: Heider B
      – PersonEntity:
          Name:
            NameFull: Picard D
      – PersonEntity:
          Name:
            NameFull: Lim JKM
      – PersonEntity:
          Name:
            NameFull: Stefanski A
      – PersonEntity:
          Name:
            NameFull: Bendrin K
      – PersonEntity:
          Name:
            NameFull: Vargas-Toscano A
      – PersonEntity:
          Name:
            NameFull: Kahlert UD
      – PersonEntity:
          Name:
            NameFull: Stühler K
      – PersonEntity:
          Name:
            NameFull: Remke M
      – PersonEntity:
          Name:
            NameFull: Elkabets M
      – PersonEntity:
          Name:
            NameFull: Grünewald TGP
      – PersonEntity:
          Name:
            NameFull: Reichert AS
      – PersonEntity:
          Name:
            NameFull: Fendt SM
      – PersonEntity:
          Name:
            NameFull: Schulze A
      – PersonEntity:
          Name:
            NameFull: Reifenberger G
      – PersonEntity:
          Name:
            NameFull: Rotblat B
      – PersonEntity:
          Name:
            NameFull: Leprivier G
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 14
              M: 05
              Text: 2024 May 14
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 15
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1