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mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models.

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Title: mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models.
Authors: Wang X; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Cottrell CA; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA., Hu X; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA.; Moderna Inc., Cambridge, MA 02139, USA., Ray R; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Bottermann M; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Villavicencio PM; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Yan Y; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Xie Z; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Warner JE; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Ellis-Pugh JR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Kalyuzhniy O; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA., Liguori A; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA., Willis JR; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA., Menis S; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA., Rämisch S; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA., Eskandarzadeh S; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA., Kubitz M; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA., Tingle R; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA., Phelps N; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA., Groschel B; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA., Himansu S; Moderna Inc., Cambridge, MA 02139, USA., Carfi A; Moderna Inc., Cambridge, MA 02139, USA., Kirsch KH; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Weldon SR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Nair U; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Schief WR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA.; Moderna Inc., Cambridge, MA 02139, USA., Batista FD; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Source: Science immunology [Sci Immunol] 2024 May 10; Vol. 9 (95), pp. eadn0622. Date of Electronic Publication: 2024 May 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2470-9468
DOI:10.1126/sciimmunol.adn0622