Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.

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Title: Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Authors: Simpson JB; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Walker ME; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Sekela JJ; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Ivey SM; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Jariwala PB; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Storch CM; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Kowalewski ME; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA., Graboski AL; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA., Lietzan AD; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Walton WG; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Davis KA; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA., Cloer EW; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Borlandelli V; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Hsiao YC; Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Roberts LR; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Perlman DH; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Liang X; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA., Overkleeft HS; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Bhatt AP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lu K; Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Redinbo MR; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA. Electronic address: redinbo@unc.edu.
Source: Cell host & microbe [Cell Host Microbe] 2024 Jun 12; Vol. 32 (6), pp. 925-944.e10. Date of Electronic Publication: 2024 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
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  Data: Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
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  Data: <searchLink fieldCode="AU" term="%22Simpson+JB%22">Simpson JB</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Walker+ME%22">Walker ME</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Sekela+JJ%22">Sekela JJ</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ivey+SM%22">Ivey SM</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Jariwala+PB%22">Jariwala PB</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Storch+CM%22">Storch CM</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kowalewski+ME%22">Kowalewski ME</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Graboski+AL%22">Graboski AL</searchLink>; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Lietzan+AD%22">Lietzan AD</searchLink>; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Walton+WG%22">Walton WG</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Davis+KA%22">Davis KA</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Cloer+EW%22">Cloer EW</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Borlandelli+V%22">Borlandelli V</searchLink>; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hsiao+YC%22">Hsiao YC</searchLink>; Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+LR%22">Roberts LR</searchLink>; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA.<br /><searchLink fieldCode="AU" term="%22Perlman+DH%22">Perlman DH</searchLink>; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA.<br /><searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; Exploratory Science Center, Merck & Co., Inc., Cambridge, MA 02141, USA.<br /><searchLink fieldCode="AU" term="%22Overkleeft+HS%22">Overkleeft HS</searchLink>; Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bhatt+AP%22">Bhatt AP</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Lu+K%22">Lu K</searchLink>; Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Redinbo+MR%22">Redinbo MR</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA. Electronic address: redinbo@unc.edu.
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