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Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.

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Title: Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Authors: Parker CC; The Royal Marsden NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK., Clarke NW; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK; Division of Cancer Sciences, University of Manchester, Manchester, UK; Department of Urology, Salford Royal Hospital, Salford, UK., Cook AD; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Kynaston H; Division of Cancer and Genetics, Cardiff University Medical School, Cardiff, UK., Catton CN; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Cross WR; Department of Urology, St James's University Hospital, Leeds, UK., Petersen PM; Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Persad RA; Department of Urology, Bristol Urological Institute, Bristol, UK., Saad F; Department of Urology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada., Bower LC; The Royal Marsden NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK; Guy's and St Thomas' NHS Foundation Trust, London, UK., Logue J; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK., Payne H; The Prostate Centre, London, UK., Forcat S; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Goldstein C; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Murphy C; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Anderson J; Department of Clinical Oncology, St James's University Hospital, Leeds, UK., Barkati M; Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada., Bottomley DM; Department of Clinical Oncology, St James's University Hospital, Leeds, UK., Branagan J; Northampton General Hospital, Northampton, UK., Choudhury A; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK; Division of Cancer Sciences, University of Manchester, Manchester, UK., Chung PWM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada., Cogley L; Derriford Hospital, Plymouth, UK., Goh CL; Royal Surrey Hospital, Guildford, UK., Hoskin P; Division of Cancer Sciences, University of Manchester, Manchester, UK; Mount Vernon Cancer Centre, Northwood, UK., Khoo V; The Royal Marsden NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK., Malone SC; The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada., Masters L; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Morris SL; Guy's and St Thomas' NHS Foundation Trust, London, UK., Nabid A; Service de Radio-Oncologie, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada., Ong AD; Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada., Raman R; Kent Oncology Centre, Kent and Canterbury Hospital, Canterbury, UK., Tarver KL; Department of Oncology, Queen's Hospital, Romford, UK., Tree AC; The Royal Marsden NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK., Worlding J; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Wylie JP; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK., Zarkar AM; Department of Oncology, University Hospitals Birmingham, Birmingham, UK., Parulekar WR; Canadian Cancer Trials Group, Queen's University, Kingston, ON, Canada., Parmar MKB; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Sydes MR; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK. Electronic address: mrcctu.radicals@ucl.ac.uk.
Corporate Authors: RADICALS investigators
Source: Lancet (London, England) [Lancet] 2024 Jun 01; Vol. 403 (10442), pp. 2405-2415. Date of Electronic Publication: 2024 May 16.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Comparative Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
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Department of Urology, St James's University Hospital, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Petersen+PM%22">Petersen PM</searchLink>; Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Persad+RA%22">Persad RA</searchLink>; Department of Urology, Bristol Urological Institute, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Saad+F%22">Saad F</searchLink>; Department of Urology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Bower+LC%22">Bower LC</searchLink>; The Royal Marsden NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK; Guy's and St Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Logue+J%22">Logue J</searchLink>; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Payne+H%22">Payne H</searchLink>; 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Mount Vernon Cancer Centre, Northwood, UK.<br /><searchLink fieldCode="AU" term="%22Khoo+V%22">Khoo V</searchLink>; The Royal Marsden NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Malone+SC%22">Malone SC</searchLink>; The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Masters+L%22">Masters L</searchLink>; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Morris+SL%22">Morris SL</searchLink>; Guy's and St Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Nabid+A%22">Nabid A</searchLink>; Service de Radio-Oncologie, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Ong+AD%22">Ong AD</searchLink>; Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Raman+R%22">Raman R</searchLink>; Kent Oncology Centre, Kent and Canterbury Hospital, Canterbury, UK.<br /><searchLink fieldCode="AU" term="%22Tarver+KL%22">Tarver KL</searchLink>; Department of Oncology, Queen's Hospital, Romford, UK.<br /><searchLink fieldCode="AU" term="%22Tree+AC%22">Tree AC</searchLink>; The Royal Marsden NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Worlding+J%22">Worlding J</searchLink>; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Wylie+JP%22">Wylie JP</searchLink>; Department of Urology, The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Zarkar+AM%22">Zarkar AM</searchLink>; Department of Oncology, University Hospitals Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Parulekar+WR%22">Parulekar WR</searchLink>; Canadian Cancer Trials Group, Queen's University, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Parmar+MKB%22">Parmar MKB</searchLink>; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sydes+MR%22">Sydes MR</searchLink>; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK. Electronic address: mrcctu.radicals@ucl.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2024 Jun 01; Vol. 403 (10442), pp. 2405-2415. <i>Date of Electronic Publication: </i>2024 May 16.
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