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The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.

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Title: The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.
Authors: Martinez DR; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.; Yale Center for Infection and Immunity, Yale School of Medicine, New Haven, CT 06510, USA., Moreira FR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Catanzaro NJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Diefenbacher MV; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Zweigart MR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Gully KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., De la Cruz G; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA., Brown AJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Adams LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Yount B; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Baric TJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Mallory ML; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Conrad H; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., May SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dong S; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Scobey DT; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Nguyen C; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Montgomery SA; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA., Perry JK; Gilead Sciences, Inc., Foster City, CA 94404, USA., Babusis D; Gilead Sciences, Inc., Foster City, CA 94404, USA., Barrett KT; Gilead Sciences, Inc., Foster City, CA 94404, USA., Nguyen AH; Gilead Sciences, Inc., Foster City, CA 94404, USA., Nguyen AQ; Gilead Sciences, Inc., Foster City, CA 94404, USA., Kalla R; Gilead Sciences, Inc., Foster City, CA 94404, USA., Bannister R; Gilead Sciences, Inc., Foster City, CA 94404, USA., Feng JY; Gilead Sciences, Inc., Foster City, CA 94404, USA., Cihlar T; Gilead Sciences, Inc., Foster City, CA 94404, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.; Rapidly Emerging Antiviral Drug Development Initiative, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Mackman RL; Gilead Sciences, Inc., Foster City, CA 94404, USA., Bilello JP; Gilead Sciences, Inc., Foster City, CA 94404, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Rapidly Emerging Antiviral Drug Development Initiative, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.; Rapidly Emerging Antiviral Drug Development Initiative, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Source: Science translational medicine [Sci Transl Med] 2024 May 22; Vol. 16 (748), pp. eadj4504. Date of Electronic Publication: 2024 May 22.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.
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  Data: <searchLink fieldCode="AU" term="%22Martinez+DR%22">Martinez DR</searchLink>; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.; Yale Center for Infection and Immunity, Yale School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Moreira+FR%22">Moreira FR</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Catanzaro+NJ%22">Catanzaro NJ</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Diefenbacher+MV%22">Diefenbacher MV</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Zweigart+MR%22">Zweigart MR</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Gully+KL%22">Gully KL</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22De+la+Cruz+G%22">De la Cruz G</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Brown+AJ%22">Brown AJ</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Adams+LE%22">Adams LE</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Yount+B%22">Yount B</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Baric+TJ%22">Baric TJ</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Mallory+ML%22">Mallory ML</searchLink>; 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Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Perry+JK%22">Perry JK</searchLink>; Gilead Sciences, Inc., Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Babusis+D%22">Babusis D</searchLink>; Gilead Sciences, Inc., Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Barrett+KT%22">Barrett KT</searchLink>; Gilead Sciences, Inc., Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+AH%22">Nguyen AH</searchLink>; Gilead Sciences, Inc., Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+AQ%22">Nguyen AQ</searchLink>; Gilead Sciences, Inc., Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Kalla+R%22">Kalla R</searchLink>; Gilead Sciences, Inc., Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Bannister+R%22">Bannister R</searchLink>; Gilead Sciences, Inc., Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Feng+JY%22">Feng JY</searchLink>; 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Rapidly Emerging Antiviral Drug Development Initiative, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Sheahan+TP%22">Sheahan TP</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.; Rapidly Emerging Antiviral Drug Development Initiative, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2024 May 22; Vol. 16 (748), pp. eadj4504. <i>Date of Electronic Publication: </i>2024 May 22.
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