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Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice.

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Title: Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice.
Authors: Sullivan JM; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Bagnell AM; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Alevy J; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Avila EM; George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI 02881, USA.; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA., Mihaljević L; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Saavedra-Rivera PC; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Kong L; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Huh JS; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., McCray BA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Aisenberg WH; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Zuberi AR; Jackson Laboratory, Bar Harbor, ME 04609, USA., Bogdanik L; Jackson Laboratory, Bar Harbor, ME 04609, USA., Lutz CM; Jackson Laboratory, Bar Harbor, ME 04609, USA., Qiu Z; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Quinlan KA; George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI 02881, USA.; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA., Searson PC; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Sumner CJ; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Source: Science translational medicine [Sci Transl Med] 2024 May 22; Vol. 16 (748), pp. eadk1358. Date of Electronic Publication: 2024 May 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice.
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  Data: <searchLink fieldCode="AU" term="%22Sullivan+JM%22">Sullivan JM</searchLink>; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Bagnell+AM%22">Bagnell AM</searchLink>; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Alevy+J%22">Alevy J</searchLink>; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Avila+EM%22">Avila EM</searchLink>; George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI 02881, USA.; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.<br /><searchLink fieldCode="AU" term="%22Mihaljević+L%22">Mihaljević L</searchLink>; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Saavedra-Rivera+PC%22">Saavedra-Rivera PC</searchLink>; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Kong+L%22">Kong L</searchLink>; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Huh+JS%22">Huh JS</searchLink>; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22McCray+BA%22">McCray BA</searchLink>; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Aisenberg+WH%22">Aisenberg WH</searchLink>; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Zuberi+AR%22">Zuberi AR</searchLink>; Jackson Laboratory, Bar Harbor, ME 04609, USA.<br /><searchLink fieldCode="AU" term="%22Bogdanik+L%22">Bogdanik L</searchLink>; Jackson Laboratory, Bar Harbor, ME 04609, USA.<br /><searchLink fieldCode="AU" term="%22Lutz+CM%22">Lutz CM</searchLink>; Jackson Laboratory, Bar Harbor, ME 04609, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+Z%22">Qiu Z</searchLink>; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Quinlan+KA%22">Quinlan KA</searchLink>; George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI 02881, USA.; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.<br /><searchLink fieldCode="AU" term="%22Searson+PC%22">Searson PC</searchLink>; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.<br /><searchLink fieldCode="AU" term="%22Sumner+CJ%22">Sumner CJ</searchLink>; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2024 May 22; Vol. 16 (748), pp. eadk1358. <i>Date of Electronic Publication: </i>2024 May 22.
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