Machine learning identifies activation of RUNX/AP-1 as drivers of mesenchymal and fibrotic regulatory programs in gastric cancer.

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Title: Machine learning identifies activation of RUNX/AP-1 as drivers of mesenchymal and fibrotic regulatory programs in gastric cancer.
Authors: Razavi-Mohseni M; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA., Huang W; Laboratory of Computational Cancer Genomics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore 138672., Guo YA; Laboratory of Computational Cancer Genomics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore 138672., Shigaki D; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA., Ho SWT; Laboratory of Cancer Epigenetic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore 138672., Tan P; Laboratory of Cancer Epigenetic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore 138672.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore 169857.; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593., Skanderup AJ; Laboratory of Computational Cancer Genomics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore 138672., Beer MA; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA; mbeer@jhu.edu skanderupamj@gis.a-star.edu.sg.
Source: Genome research [Genome Res] 2024 Jun 25; Vol. 34 (5), pp. 680-695. Date of Electronic Publication: 2024 Jun 25.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9518021 Publication Model: Electronic Cited Medium: Internet ISSN: 1549-5469 (Electronic) Linking ISSN: 10889051 NLM ISO Abbreviation: Genome Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Machine learning identifies activation of RUNX/AP-1 as drivers of mesenchymal and fibrotic regulatory programs in gastric cancer.
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  Data: <searchLink fieldCode="AU" term="%22Razavi-Mohseni+M%22">Razavi-Mohseni M</searchLink>; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; Laboratory of Computational Cancer Genomics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore 138672.<br /><searchLink fieldCode="AU" term="%22Guo+YA%22">Guo YA</searchLink>; Laboratory of Computational Cancer Genomics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore 138672.<br /><searchLink fieldCode="AU" term="%22Shigaki+D%22">Shigaki D</searchLink>; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.<br /><searchLink fieldCode="AU" term="%22Ho+SWT%22">Ho SWT</searchLink>; Laboratory of Cancer Epigenetic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore 138672.<br /><searchLink fieldCode="AU" term="%22Tan+P%22">Tan P</searchLink>; Laboratory of Cancer Epigenetic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore 138672.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore 169857.; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593.<br /><searchLink fieldCode="AU" term="%22Skanderup+AJ%22">Skanderup AJ</searchLink>; Laboratory of Computational Cancer Genomics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore 138672.<br /><searchLink fieldCode="AU" term="%22Beer+MA%22">Beer MA</searchLink>; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA; mbeer@jhu.edu skanderupamj@gis.a-star.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%229518021%22">Genome research</searchLink> [Genome Res] 2024 Jun 25; Vol. 34 (5), pp. 680-695. <i>Date of Electronic Publication: </i>2024 Jun 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cold+Spring+Harbor+Laboratory+Press%22">Cold Spring Harbor Laboratory Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9518021 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1549-5469 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210889051%22">10889051 </searchLink><i>NLM ISO Abbreviation: </i>Genome Res <i>Subsets: </i>MEDLINE
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        Value: 10.1101/gr.278565.123
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      – TitleFull: Machine learning identifies activation of RUNX/AP-1 as drivers of mesenchymal and fibrotic regulatory programs in gastric cancer.
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              Text: 2024 Jun 25
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