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TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution.

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Title: TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution.
Authors: Qu B; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; European Virus Bioinformatics Center, 07743 Jena, Germany., Miskey C; Division of Medical Biotechnology, Paul-Ehrlich-Institut, 63225 Langen, Germany., Gömer A; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Kleinert RDV; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Ibanez SC; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany., Eberle R; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany., Ebenig A; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Postmus D; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Nocke MK; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Herrmann M; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Itotia TK; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Department of Physical Sciences, Chuka University, 60400 Chuka, Kenya., Herrmann ST; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Heinen N; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Höck S; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Hastert FD; Division of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany., von Rhein C; Division of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany., Schürmann C; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Li X; Department of Cardiology, Medical University Hospital, 69120 Heidelberg, Germany., van Zandbergen G; Division of Immunology, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Institute for Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, 55131 Mainz, Germany.; Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg-University Mainz, 55131 Mainz, Germany., Widera M; Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany., Ciesek S; Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, 60596 Frankfurt am Main, Germany.; German Center for Infection Research, 38124 Braunschweig, Germany., Schnierle BS; Division of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany., Tarr AW; School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2UH, United Kingdom.; School of Life Sciences and National Institute for Health and Care Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom., Steinmann E; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Goffinet C; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Pfaender S; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.; Research Unit Emerging Viruses, Leibniz Institute of Virology, 20251 Hamburg, Germany.; University of Lübeck, 23562 Lübeck, Germany., Locker JK; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Justus Liebig University Geissen, 35390 Giessen, Germany., Mühlebach MD; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; German Center for Infection Research, 63225 Giessen-Marburg-Langen, Germany., Todt D; European Virus Bioinformatics Center, 07743 Jena, Germany.; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Brown RJP; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jun 04; Vol. 121 (23), pp. e2407437121. Date of Electronic Publication: 2024 May 30.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution.
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  Data: <searchLink fieldCode="AU" term="%22Qu+B%22">Qu B</searchLink>; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; European Virus Bioinformatics Center, 07743 Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Miskey+C%22">Miskey C</searchLink>; Division of Medical Biotechnology, Paul-Ehrlich-Institut, 63225 Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Gömer+A%22">Gömer A</searchLink>; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Kleinert+RDV%22">Kleinert RDV</searchLink>; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Ibanez+SC%22">Ibanez SC</searchLink>; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Eberle+R%22">Eberle R</searchLink>; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Ebenig+A%22">Ebenig A</searchLink>; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Postmus+D%22">Postmus D</searchLink>; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Nocke+MK%22">Nocke MK</searchLink>; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Herrmann+M%22">Herrmann M</searchLink>; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Itotia+TK%22">Itotia TK</searchLink>; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Department of Physical Sciences, Chuka University, 60400 Chuka, Kenya.<br /><searchLink fieldCode="AU" term="%22Herrmann+ST%22">Herrmann ST</searchLink>; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Heinen+N%22">Heinen N</searchLink>; 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Institute for Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, 55131 Mainz, Germany.; Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Widera+M%22">Widera M</searchLink>; Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Ciesek+S%22">Ciesek S</searchLink>; Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, 60596 Frankfurt am Main, Germany.; German Center for Infection Research, 38124 Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Schnierle+BS%22">Schnierle BS</searchLink>; Division of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Tarr+AW%22">Tarr AW</searchLink>; School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2UH, United Kingdom.; School of Life Sciences and National Institute for Health and Care Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Steinmann+E%22">Steinmann E</searchLink>; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Goffinet+C%22">Goffinet C</searchLink>; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pfaender+S%22">Pfaender S</searchLink>; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.; Research Unit Emerging Viruses, Leibniz Institute of Virology, 20251 Hamburg, Germany.; University of Lübeck, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Locker+JK%22">Locker JK</searchLink>; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Justus Liebig University Geissen, 35390 Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Mühlebach+MD%22">Mühlebach MD</searchLink>; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; German Center for Infection Research, 63225 Giessen-Marburg-Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Todt+D%22">Todt D</searchLink>; European Virus Bioinformatics Center, 07743 Jena, Germany.; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Brown+RJP%22">Brown RJP</searchLink>; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.
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