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Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels.

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Title: Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels.
Authors: Yan S; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA., Santoro A; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA., Niphakis MJ; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Pinto AM; The Salk Institute for Biological Studies, 10010 N. Torey Pines Rd, La Jolla, CA, 92037-1002, USA., Jacobs CL; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA., Ahmad R; Immunology and Microbiology Department, Dasman Diabetes Institute, Jasim Mohamad Al Bahar St., Kuwait City, Kuwait., Suciu RM; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Fonslow BR; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Herbst-Graham RA; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Ngo N; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Henry CL; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Herbst DM; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Saghatelian A; The Salk Institute for Biological Studies, 10010 N. Torey Pines Rd, La Jolla, CA, 92037-1002, USA., Kahn BB; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA.; Broad Institute of Harvard and MIT, 320 Charles St., Cambridge, MA, 02141, USA., Rosen ED; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. erosen@bidmc.harvard.edu.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA. erosen@bidmc.harvard.edu.; Broad Institute of Harvard and MIT, 320 Charles St., Cambridge, MA, 02141, USA. erosen@bidmc.harvard.edu.
Source: Nature communications [Nat Commun] 2024 May 30; Vol. 15 (1), pp. 4605. Date of Electronic Publication: 2024 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels.
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  Data: <searchLink fieldCode="AU" term="%22Yan+S%22">Yan S</searchLink>; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA.<br /><searchLink fieldCode="AU" term="%22Santoro+A%22">Santoro A</searchLink>; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA.<br /><searchLink fieldCode="AU" term="%22Niphakis+MJ%22">Niphakis MJ</searchLink>; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA.<br /><searchLink fieldCode="AU" term="%22Pinto+AM%22">Pinto AM</searchLink>; The Salk Institute for Biological Studies, 10010 N. Torey Pines Rd, La Jolla, CA, 92037-1002, USA.<br /><searchLink fieldCode="AU" term="%22Jacobs+CL%22">Jacobs CL</searchLink>; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA.<br /><searchLink fieldCode="AU" term="%22Ahmad+R%22">Ahmad R</searchLink>; Immunology and Microbiology Department, Dasman Diabetes Institute, Jasim Mohamad Al Bahar St., Kuwait City, Kuwait.<br /><searchLink fieldCode="AU" term="%22Suciu+RM%22">Suciu RM</searchLink>; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA.<br /><searchLink fieldCode="AU" term="%22Fonslow+BR%22">Fonslow BR</searchLink>; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA.<br /><searchLink fieldCode="AU" term="%22Herbst-Graham+RA%22">Herbst-Graham RA</searchLink>; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA.<br /><searchLink fieldCode="AU" term="%22Ngo+N%22">Ngo N</searchLink>; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA.<br /><searchLink fieldCode="AU" term="%22Henry+CL%22">Henry CL</searchLink>; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA.<br /><searchLink fieldCode="AU" term="%22Herbst+DM%22">Herbst DM</searchLink>; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA.<br /><searchLink fieldCode="AU" term="%22Saghatelian+A%22">Saghatelian A</searchLink>; The Salk Institute for Biological Studies, 10010 N. Torey Pines Rd, La Jolla, CA, 92037-1002, USA.<br /><searchLink fieldCode="AU" term="%22Kahn+BB%22">Kahn BB</searchLink>; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA.; Broad Institute of Harvard and MIT, 320 Charles St., Cambridge, MA, 02141, USA.<br /><searchLink fieldCode="AU" term="%22Rosen+ED%22">Rosen ED</searchLink>; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. erosen@bidmc.harvard.edu.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA. erosen@bidmc.harvard.edu.; Broad Institute of Harvard and MIT, 320 Charles St., Cambridge, MA, 02141, USA. erosen@bidmc.harvard.edu.
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        Value: 10.1038/s41467-024-48220-5
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