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A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.

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Title: A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.
Authors: Hulin-Curtis S; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Geary JK; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address: gearyj2@cardiff.ac.uk., MacLachlan BJ; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Altmann DM; Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK., Baillon L; Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK., Cole DK; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Greenshields-Watson A; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Department of Statistics, University of Oxford, Oxford OX1 3LB, UK., Hesketh SJ; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Humphreys IR; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Jones IM; School of Biological Sciences, University of Reading, Reading RG6 6AH, UK., Lauder SN; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Mason GH; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Smart K; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Scourfield DO; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Scott J; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Sukhova K; Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK., Stanton RJ; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Wall A; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Rizkallah PJ; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Barclay WS; Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK., Gallimore A; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Godkin A; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address: godkinaj@cardiff.ac.uk.
Source: Cell reports [Cell Rep] 2024 Jun 25; Vol. 43 (6), pp. 114259. Date of Electronic Publication: 2024 May 30.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4<superscript>+</superscript> T cell activation.
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  Data: <searchLink fieldCode="AU" term="%22Hulin-Curtis+S%22">Hulin-Curtis S</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Geary+JK%22">Geary JK</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address: gearyj2@cardiff.ac.uk.<br /><searchLink fieldCode="AU" term="%22MacLachlan+BJ%22">MacLachlan BJ</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Altmann+DM%22">Altmann DM</searchLink>; Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Baillon+L%22">Baillon L</searchLink>; Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Cole+DK%22">Cole DK</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Greenshields-Watson+A%22">Greenshields-Watson A</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Department of Statistics, University of Oxford, Oxford OX1 3LB, UK.<br /><searchLink fieldCode="AU" term="%22Hesketh+SJ%22">Hesketh SJ</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Humphreys+IR%22">Humphreys IR</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Jones+IM%22">Jones IM</searchLink>; School of Biological Sciences, University of Reading, Reading RG6 6AH, UK.<br /><searchLink fieldCode="AU" term="%22Lauder+SN%22">Lauder SN</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Mason+GH%22">Mason GH</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Smart+K%22">Smart K</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Scourfield+DO%22">Scourfield DO</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Scott+J%22">Scott J</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Sukhova+K%22">Sukhova K</searchLink>; Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Stanton+RJ%22">Stanton RJ</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Wall+A%22">Wall A</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Rizkallah+PJ%22">Rizkallah PJ</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Barclay+WS%22">Barclay WS</searchLink>; Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Gallimore+A%22">Gallimore A</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Godkin+A%22">Godkin A</searchLink>; Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address: godkinaj@cardiff.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2024 Jun 25; Vol. 43 (6), pp. 114259. <i>Date of Electronic Publication: </i>2024 May 30.
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