First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial.
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| Title: | First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial. |
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| Authors: | Fürstenau M; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany. Electronic address: moritz.fuerstenau@uk-koeln.de., Kater AP; Department of Hematology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands., Robrecht S; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., von Tresckow J; Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Zhang C; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Gregor M; Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland., Thornton P; Department of Haematology, Beaumont Hospital, Dublin, Ireland., Staber PB; Department of Medicine I, Medical University of Vienna, Vienna, Austria., Tadmor T; Hematology, Bnai-Zion Medical Center, Haifa, Israel., Lindström V; Comprehensive Cancer Center, Department of Hematology, Helsinki University Hospital and University of Helsinki, Finland., Juliusson G; Department of Hematology, Skåne University Hospital, Lund, Sweden., Janssens A; Universitaire Ziekenhuizen Leuven, Leuven, Belgium., Levin MD; Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands., da Cunha-Bang C; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Schneider C; Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany., Goldschmidt N; Department of Hematology, Hadassah Medical Center, Jerusalem, Israel., Vandenberghe E; St James Hospital, Dublin, Ireland., Rossi D; Division of Hematology, Oncology Institute of Southern Switzerland and Institute of Oncology Research, EOC and USI, Bellinzona, Switzerland., Benz R; Division of Hematology and Oncology, Cantonal Hospital, Münsterlingen, Switzerland., Nösslinger T; Medical University of Vienna, and the Department of Hematology and Oncology, Hanusch Hospital, Vienna, Austria., Heintel D; Division of Medicine I, Klinik Ottakring, Vienna, Austria., Poulsen CB; Department of Hematology, Zealand University Hospital, Roskilde, Denmark., Christiansen I; Department of Hematology, Aalborg University Hospital, Aalborg, Denmark., Frederiksen H; Department of Hematology, Odense University Hospital, Odense, Denmark., Enggaard L; Department of Hematology, Herlev Hospital, Herlev, Denmark., Posthuma EFM; Department of Internal Medicine, Reinier The Graaf Hospital, Delft, Netherlands., Issa DE; Jeroen Bosch hospital, Den Bosch, Netherlands., Visser HPJ; Department of Internal Medicine, Noordwest ziekenhuisgroep, Alkmaar, Netherlands., Bellido M; Department of Hematology, Groningen University Medical Center, University of Groningen, Groningen, Netherlands., Kutsch N; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Dürig J; Department of Internal Medicine, St Josef Krankenhaus Werden, University Medicine Essen, Essen, Germany., Stehle A; Department of Hematology and Oncology, Robert-Bosch-Krankenhaus, Stuttgart, Germany., Vöhringer M; Department of Hematology and Oncology, Robert-Bosch-Krankenhaus, Stuttgart, Germany., Böttcher S; Department of Medicine III Hematology, Oncology and Palliative Care, University Hospital Rostock, Rostock, Germany., Schulte C; Gemeinschaftspraxis für Hämatologie und Onkologie, Dortmund, Germany., Simon F; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Fink AM; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Fischer K; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Holmes EE; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Kreuzer KA; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Ritgen M; Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany., Brüggemann M; Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany., Tausch E; Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany., Stilgenbauer S; Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany., Hallek M; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Niemann CU; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Eichhorst B; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany. |
| Source: | The Lancet. Oncology [Lancet Oncol] 2024 Jun; Vol. 25 (6), pp. 744-759. |
| Publication Type: | Journal Article; Clinical Trial, Phase III; Multicenter Study; Randomized Controlled Trial; Comparative Study; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 38821083 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Fürstenau+M%22">Fürstenau M</searchLink>; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany. Electronic address: moritz.fuerstenau@uk-koeln.de.<br /><searchLink fieldCode="AU" term="%22Kater+AP%22">Kater AP</searchLink>; Department of Hematology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Robrecht+S%22">Robrecht S</searchLink>; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22von+Tresckow+J%22">von Tresckow J</searchLink>; Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Gregor+M%22">Gregor M</searchLink>; Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Thornton+P%22">Thornton P</searchLink>; Department of Haematology, Beaumont Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Staber+PB%22">Staber PB</searchLink>; Department of Medicine I, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Tadmor+T%22">Tadmor T</searchLink>; Hematology, Bnai-Zion Medical Center, Haifa, Israel.<br /><searchLink fieldCode="AU" term="%22Lindström+V%22">Lindström V</searchLink>; Comprehensive Cancer Center, Department of Hematology, Helsinki University Hospital and University of Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Juliusson+G%22">Juliusson G</searchLink>; Department of Hematology, Skåne University Hospital, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Janssens+A%22">Janssens A</searchLink>; Universitaire Ziekenhuizen Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Levin+MD%22">Levin MD</searchLink>; Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22da+Cunha-Bang+C%22">da Cunha-Bang C</searchLink>; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Schneider+C%22">Schneider C</searchLink>; Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Goldschmidt+N%22">Goldschmidt N</searchLink>; Department of Hematology, Hadassah Medical Center, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Vandenberghe+E%22">Vandenberghe E</searchLink>; St James Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Rossi+D%22">Rossi D</searchLink>; Division of Hematology, Oncology Institute of Southern Switzerland and Institute of Oncology Research, EOC and USI, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Benz+R%22">Benz R</searchLink>; Division of Hematology and Oncology, Cantonal Hospital, Münsterlingen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Nösslinger+T%22">Nösslinger T</searchLink>; Medical University of Vienna, and the Department of Hematology and Oncology, Hanusch Hospital, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Heintel+D%22">Heintel D</searchLink>; Division of Medicine I, Klinik Ottakring, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Poulsen+CB%22">Poulsen CB</searchLink>; Department of Hematology, Zealand University Hospital, Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22Christiansen+I%22">Christiansen I</searchLink>; Department of Hematology, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Frederiksen+H%22">Frederiksen H</searchLink>; Department of Hematology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Enggaard+L%22">Enggaard L</searchLink>; Department of Hematology, Herlev Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Posthuma+EFM%22">Posthuma EFM</searchLink>; Department of Internal Medicine, Reinier The Graaf Hospital, Delft, Netherlands.<br /><searchLink fieldCode="AU" term="%22Issa+DE%22">Issa DE</searchLink>; Jeroen Bosch hospital, Den Bosch, Netherlands.<br /><searchLink fieldCode="AU" term="%22Visser+HPJ%22">Visser HPJ</searchLink>; Department of Internal Medicine, Noordwest ziekenhuisgroep, Alkmaar, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bellido+M%22">Bellido M</searchLink>; Department of Hematology, Groningen University Medical Center, University of Groningen, Groningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kutsch+N%22">Kutsch N</searchLink>; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Dürig+J%22">Dürig J</searchLink>; Department of Internal Medicine, St Josef Krankenhaus Werden, University Medicine Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Stehle+A%22">Stehle A</searchLink>; Department of Hematology and Oncology, Robert-Bosch-Krankenhaus, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Vöhringer+M%22">Vöhringer M</searchLink>; Department of Hematology and Oncology, Robert-Bosch-Krankenhaus, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Böttcher+S%22">Böttcher S</searchLink>; Department of Medicine III Hematology, Oncology and Palliative Care, University Hospital Rostock, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Schulte+C%22">Schulte C</searchLink>; Gemeinschaftspraxis für Hämatologie und Onkologie, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Simon+F%22">Simon F</searchLink>; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Fink+AM%22">Fink AM</searchLink>; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer+K%22">Fischer K</searchLink>; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Holmes+EE%22">Holmes EE</searchLink>; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kreuzer+KA%22">Kreuzer KA</searchLink>; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ritgen+M%22">Ritgen M</searchLink>; Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Brüggemann+M%22">Brüggemann M</searchLink>; Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Tausch+E%22">Tausch E</searchLink>; Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Stilgenbauer+S%22">Stilgenbauer S</searchLink>; Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Hallek+M%22">Hallek M</searchLink>; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Niemann+CU%22">Niemann CU</searchLink>; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Eichhorst+B%22">Eichhorst B</searchLink>; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100957246%22">The Lancet. Oncology</searchLink> [Lancet Oncol] 2024 Jun; Vol. 25 (6), pp. 744-759. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase III; Multicenter Study; Randomized Controlled Trial; Comparative Study; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lancet+Pub%2E+Group%22">Lancet Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100957246 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-5488 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214702045%22">14702045 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Oncol <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S1470-2045(24)00196-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 744 Titles: – TitleFull: First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fürstenau M – PersonEntity: Name: NameFull: Kater AP – PersonEntity: Name: NameFull: Robrecht S – PersonEntity: Name: NameFull: von Tresckow J – PersonEntity: Name: NameFull: Zhang C – PersonEntity: Name: NameFull: Gregor M – PersonEntity: Name: NameFull: Thornton P – PersonEntity: Name: NameFull: Staber PB – PersonEntity: Name: NameFull: Tadmor T – PersonEntity: Name: NameFull: Lindström V – PersonEntity: Name: NameFull: Juliusson G – PersonEntity: Name: NameFull: Janssens A – PersonEntity: Name: NameFull: Levin MD – PersonEntity: Name: NameFull: da Cunha-Bang C – PersonEntity: Name: NameFull: Schneider C – PersonEntity: Name: NameFull: Goldschmidt N – PersonEntity: Name: NameFull: Vandenberghe E – PersonEntity: Name: NameFull: Rossi D – PersonEntity: Name: NameFull: Benz R – PersonEntity: Name: NameFull: Nösslinger T – PersonEntity: Name: NameFull: Heintel D – PersonEntity: Name: NameFull: Poulsen CB – PersonEntity: Name: NameFull: Christiansen I – PersonEntity: Name: NameFull: Frederiksen H – PersonEntity: Name: NameFull: Enggaard L – PersonEntity: Name: NameFull: Posthuma EFM – PersonEntity: Name: NameFull: Issa DE – PersonEntity: Name: NameFull: Visser HPJ – PersonEntity: Name: NameFull: Bellido M – PersonEntity: Name: NameFull: Kutsch N – PersonEntity: Name: NameFull: Dürig J – PersonEntity: Name: NameFull: Stehle A – PersonEntity: Name: NameFull: Vöhringer M – PersonEntity: Name: NameFull: Böttcher S – PersonEntity: Name: NameFull: Schulte C – PersonEntity: Name: NameFull: Simon F – PersonEntity: Name: NameFull: Fink AM – PersonEntity: Name: NameFull: Fischer K – PersonEntity: Name: NameFull: Holmes EE – PersonEntity: Name: NameFull: Kreuzer KA – PersonEntity: Name: NameFull: Ritgen M – PersonEntity: Name: NameFull: Brüggemann M – PersonEntity: Name: NameFull: Tausch E – PersonEntity: Name: NameFull: Stilgenbauer S – PersonEntity: Name: NameFull: Hallek M – PersonEntity: Name: NameFull: Niemann CU – PersonEntity: Name: NameFull: Eichhorst B IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2024 Jun Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1474-5488 Numbering: – Type: volume Value: 25 – Type: issue Value: 6 Titles: – TitleFull: The Lancet. Oncology Type: main |
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