First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial.

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Title: First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial.
Authors: Fürstenau M; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany. Electronic address: moritz.fuerstenau@uk-koeln.de., Kater AP; Department of Hematology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands., Robrecht S; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., von Tresckow J; Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Zhang C; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Gregor M; Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland., Thornton P; Department of Haematology, Beaumont Hospital, Dublin, Ireland., Staber PB; Department of Medicine I, Medical University of Vienna, Vienna, Austria., Tadmor T; Hematology, Bnai-Zion Medical Center, Haifa, Israel., Lindström V; Comprehensive Cancer Center, Department of Hematology, Helsinki University Hospital and University of Helsinki, Finland., Juliusson G; Department of Hematology, Skåne University Hospital, Lund, Sweden., Janssens A; Universitaire Ziekenhuizen Leuven, Leuven, Belgium., Levin MD; Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands., da Cunha-Bang C; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Schneider C; Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany., Goldschmidt N; Department of Hematology, Hadassah Medical Center, Jerusalem, Israel., Vandenberghe E; St James Hospital, Dublin, Ireland., Rossi D; Division of Hematology, Oncology Institute of Southern Switzerland and Institute of Oncology Research, EOC and USI, Bellinzona, Switzerland., Benz R; Division of Hematology and Oncology, Cantonal Hospital, Münsterlingen, Switzerland., Nösslinger T; Medical University of Vienna, and the Department of Hematology and Oncology, Hanusch Hospital, Vienna, Austria., Heintel D; Division of Medicine I, Klinik Ottakring, Vienna, Austria., Poulsen CB; Department of Hematology, Zealand University Hospital, Roskilde, Denmark., Christiansen I; Department of Hematology, Aalborg University Hospital, Aalborg, Denmark., Frederiksen H; Department of Hematology, Odense University Hospital, Odense, Denmark., Enggaard L; Department of Hematology, Herlev Hospital, Herlev, Denmark., Posthuma EFM; Department of Internal Medicine, Reinier The Graaf Hospital, Delft, Netherlands., Issa DE; Jeroen Bosch hospital, Den Bosch, Netherlands., Visser HPJ; Department of Internal Medicine, Noordwest ziekenhuisgroep, Alkmaar, Netherlands., Bellido M; Department of Hematology, Groningen University Medical Center, University of Groningen, Groningen, Netherlands., Kutsch N; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Dürig J; Department of Internal Medicine, St Josef Krankenhaus Werden, University Medicine Essen, Essen, Germany., Stehle A; Department of Hematology and Oncology, Robert-Bosch-Krankenhaus, Stuttgart, Germany., Vöhringer M; Department of Hematology and Oncology, Robert-Bosch-Krankenhaus, Stuttgart, Germany., Böttcher S; Department of Medicine III Hematology, Oncology and Palliative Care, University Hospital Rostock, Rostock, Germany., Schulte C; Gemeinschaftspraxis für Hämatologie und Onkologie, Dortmund, Germany., Simon F; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Fink AM; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Fischer K; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Holmes EE; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Kreuzer KA; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Ritgen M; Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany., Brüggemann M; Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany., Tausch E; Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany., Stilgenbauer S; Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany., Hallek M; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany., Niemann CU; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Eichhorst B; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany.
Source: The Lancet. Oncology [Lancet Oncol] 2024 Jun; Vol. 25 (6), pp. 744-759.
Publication Type: Journal Article; Clinical Trial, Phase III; Multicenter Study; Randomized Controlled Trial; Comparative Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial.
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German CLL Study Group, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Gregor+M%22">Gregor M</searchLink>; Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Thornton+P%22">Thornton P</searchLink>; Department of Haematology, Beaumont Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Staber+PB%22">Staber PB</searchLink>; Department of Medicine I, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Tadmor+T%22">Tadmor T</searchLink>; Hematology, Bnai-Zion Medical Center, Haifa, Israel.<br /><searchLink fieldCode="AU" term="%22Lindström+V%22">Lindström V</searchLink>; Comprehensive Cancer Center, Department of Hematology, Helsinki University Hospital and University of Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Juliusson+G%22">Juliusson G</searchLink>; Department of Hematology, Skåne University Hospital, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Janssens+A%22">Janssens A</searchLink>; 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Division of Hematology and Oncology, Cantonal Hospital, Münsterlingen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Nösslinger+T%22">Nösslinger T</searchLink>; Medical University of Vienna, and the Department of Hematology and Oncology, Hanusch Hospital, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Heintel+D%22">Heintel D</searchLink>; Division of Medicine I, Klinik Ottakring, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Poulsen+CB%22">Poulsen CB</searchLink>; Department of Hematology, Zealand University Hospital, Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22Christiansen+I%22">Christiansen I</searchLink>; Department of Hematology, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Frederiksen+H%22">Frederiksen H</searchLink>; Department of Hematology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Enggaard+L%22">Enggaard L</searchLink>; Department of Hematology, Herlev Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Posthuma+EFM%22">Posthuma EFM</searchLink>; 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Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany; German CLL Study Group, University of Cologne, Cologne, Germany.
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