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Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models.

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Title: Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models.
Authors: Hynds RE; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. rob.hynds@ucl.ac.uk.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. rob.hynds@ucl.ac.uk.; Epithelial Cell Biology in ENT Research Group (EpiCENTR), Developmental Biology and Cancer, Great Ormond Street University College London Institute of Child Health, London, UK. rob.hynds@ucl.ac.uk., Huebner A; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Pearce DR; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Hill MS; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Akarca AU; Department of Cellular Pathology, University College London Hospitals, London, UK., Moore DA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Department of Cellular Pathology, University College London Hospitals, London, UK., Ward S; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Advanced Sequencing Facility, The Francis Crick Institute, London, UK., Gowers KHC; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Karasaki T; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Metastasis Laboratory, University College London Cancer Institute, London, UK., Al Bakir M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Wilson GA; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Pich O; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Martínez-Ruiz C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Hossain ASMM; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University of Manchester, Manchester, UK., Pearce SP; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University of Manchester, Manchester, UK., Sivakumar M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Department of Cellular Pathology, University College London Hospitals, London, UK., Ben Aissa A; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK., Grönroos E; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Chandrasekharan D; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Kolluri KK; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Towns R; Biological Services Unit, University College London, London, UK., Wang K; School of Medicine, University of Leeds, Leeds, UK., Cook DE; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Bosshard-Carter L; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Naceur-Lombardelli C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Rowan AJ; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Veeriah S; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Litchfield K; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Tumour Immunogenomics and Immunosurveillance Laboratory, University College London Cancer Institute, London, UK., Crosbie PAJ; Cancer Research UK Lung Cancer Centre of Excellence, University of Manchester, Manchester, UK.; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK., Dive C; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University of Manchester, Manchester, UK., Quezada SA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK., Janes SM; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Jamal-Hanjani M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Metastasis Laboratory, University College London Cancer Institute, London, UK.; Department of Oncology, University College London Hospitals, London, UK., Marafioti T; Department of Cellular Pathology, University College London Hospitals, London, UK., McGranahan N; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk., Swanton C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. charles.swanton@crick.ac.uk.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. charles.swanton@crick.ac.uk.; Department of Oncology, University College London Hospitals, London, UK. charles.swanton@crick.ac.uk.
Corporate Authors: TRACERx consortium
Source: Nature communications [Nat Commun] 2024 May 31; Vol. 15 (1), pp. 4653. Date of Electronic Publication: 2024 May 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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