In vivo mRNA expression of a multi-mechanistic mAb combination protects against Staphylococcus aureus infection.

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Title: In vivo mRNA expression of a multi-mechanistic mAb combination protects against Staphylococcus aureus infection.
Authors: Tkaczyk C; AstraZeneca, Early Vaccines & Immune Therapies, Gaithersburg, MD 20878, USA. Electronic address: christine.tkaczyk@astrazeneca.com., Newton M; AstraZeneca, BioPharmaceutical Development, BioPharmaceuticals R&D, Gaithersburg, MD 20878, USA., Patnaik MM; AstraZeneca, Early Vaccines & Immune Therapies, Gaithersburg, MD 20878, USA., Thom G; AstraZeneca, Discovery Sciences, BioPharmaceuticals R&D, Cambridge CB21 6GH, UK., Strain M; AstraZeneca, Biologics Engineering, BioPharmaceuticals R&D, Cambridge CB216GH, UK., Gamson A; AstraZeneca, Early Vaccines & Immune Therapies, Gaithersburg, MD 20878, USA., Daramola O; AstraZeneca, BioPharmaceutical Development, BioPharmaceuticals R&D, Cambridge CB21 6GH, UK., Murthy A; AstraZeneca, BioPharmaceutical Development, BioPharmaceuticals R&D, Cambridge CB21 6GH, UK., Douthwaite J; AstraZeneca, Discovery Sciences, BioPharmaceuticals R&D, Cambridge CB21 6GH, UK., Stepanov O; Clinical Pharmacology and Pharmacometrics, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 8PA, UK., Boger E; Drug Metabolism and Pharmacokinetics, Research and Early Development, Respirator & immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Yang H; Clinical Pharmacology and Pharmacometrics, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Esser MT; AstraZeneca, Early Vaccines & Immune Therapies, Gaithersburg, MD 20878, USA., Lidwell A; AstraZeneca, Early Vaccines & Immune Therapies, Gaithersburg, MD 20878, USA., DiGiandomenico A; AstraZeneca, Early Vaccines & Immune Therapies, Gaithersburg, MD 20878, USA., Santos L; AstraZeneca, BioPharmaceutical Development, BioPharmaceuticals R&D, Gaithersburg, MD 20878, USA., Sellman BR; AstraZeneca, Early Vaccines & Immune Therapies, Gaithersburg, MD 20878, USA.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Aug 07; Vol. 32 (8), pp. 2505-2518. Date of Electronic Publication: 2024 May 31.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2024.05.036