Induction-concurrent chemoradiotherapy with or without sintilimab in patients with locoregionally advanced nasopharyngeal carcinoma in China (CONTINUUM): a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial.
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| Title: | Induction-concurrent chemoradiotherapy with or without sintilimab in patients with locoregionally advanced nasopharyngeal carcinoma in China (CONTINUUM): a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial. |
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| Authors: | Liu X; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China; Chinese Society of Clinical Oncology, Beijing, China., Zhang Y; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Yang KY; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zhang N; Department of Radiation Oncology, First People's Hospital of Foshan, Foshan, China., Jin F; Department of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China., Zou GR; Department of Oncology, Panyu Central Hospital, Guangzhou, China., Zhu XD; Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China., Xie FY; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China; Chinese Society of Clinical Oncology, Beijing, China., Liang XY; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Li WF; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., He ZY; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Chen NY; Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China., Hu WH; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Wu HJ; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Shi M; Department of Radiation Oncology, Xijing Hospital, Air Force Medical University, Xi'an, China., Zhou GQ; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Mao YP; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China; Chinese Society of Clinical Oncology, Beijing, China., Guo R; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Sun R; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Huang J; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Liang SQ; Department of Radiation Oncology, First People's Hospital of Foshan, Foshan, China., Wu WL; Department of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China., Su Z; Department of Oncology, Panyu Central Hospital, Guangzhou, China., Li L; Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China., Ai P; Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China., He YX; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Zang J; Department of Radiation Oncology, Xijing Hospital, Air Force Medical University, Xi'an, China., Chen L; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Lin L; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Huang SH; Department of Radiation Oncology, Princess Margaret Cancer Center, University of Toronto, ON, Canada., Xu C; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Lv JW; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Li YQ; Emergency Department, Sun Yat-sen University Cancer Center, Guangzhou, China., Hong SB; Department of Endocrinology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Jie YS; Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Li H; Department of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Huang SW; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Liang YL; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Wang YQ; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Peng YL; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Zhu JH; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China., Zang SB; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China., Liu SR; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China., Lin QG; Department of Ultrasound, Sun Yat-sen University Cancer Center, Guangzhou, China., Li HJ; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, China., Tian L; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, China., Liu LZ; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, China., Zhao HY; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China., Lin AH; Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China., Li JB; Clinical Trials Center, Sun Yat-sen University Cancer Center, Guangzhou, China., Liu N; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China; Chinese Society of Clinical Oncology, Beijing, China., Tang LL; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China; Chinese Society of Clinical Oncology, Beijing, China., Chen YP; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China; Chinese Society of Clinical Oncology, Beijing, China., Sun Y; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China; Chinese Society of Clinical Oncology, Beijing, China., Ma J; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China; Chinese Society of Clinical Oncology, Beijing, China. Electronic address: majun2@mail.sysu.edu.cn. |
| Source: | Lancet (London, England) [Lancet] 2024 Jun 22; Vol. 403 (10445), pp. 2720-2731. Date of Electronic Publication: 2024 May 30. |
| Publication Type: | Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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