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A PARP2-specific active site α-helix melts to permit DNA damage-induced enzymatic activation.

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Title: A PARP2-specific active site α-helix melts to permit DNA damage-induced enzymatic activation.
Authors: Smith-Pillet ES; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute.; Graduate Program in Biochemistry, Biophysics, Chemical Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140-6059 USA., Billur R; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute., Langelier MF; Département de Biochimie et Médecine Moléculaire, Université de Montréal Montréal, (Québec), H3C 3J7 Canada., Talele TT; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439 USA., Pascal JM; Département de Biochimie et Médecine Moléculaire, Université de Montréal Montréal, (Québec), H3C 3J7 Canada., Black BE; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute.; Graduate Program in Biochemistry, Biophysics, Chemical Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140-6059 USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 20. Date of Electronic Publication: 2024 May 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: <searchLink fieldCode="AU" term="%22Smith-Pillet+ES%22">Smith-Pillet ES</searchLink>; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute.; Graduate Program in Biochemistry, Biophysics, Chemical Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140-6059 USA.<br /><searchLink fieldCode="AU" term="%22Billur+R%22">Billur R</searchLink>; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute.<br /><searchLink fieldCode="AU" term="%22Langelier+MF%22">Langelier MF</searchLink>; Département de Biochimie et Médecine Moléculaire, Université de Montréal Montréal, (Québec), H3C 3J7 Canada.<br /><searchLink fieldCode="AU" term="%22Talele+TT%22">Talele TT</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439 USA.<br /><searchLink fieldCode="AU" term="%22Pascal+JM%22">Pascal JM</searchLink>; Département de Biochimie et Médecine Moléculaire, Université de Montréal Montréal, (Québec), H3C 3J7 Canada.<br /><searchLink fieldCode="AU" term="%22Black+BE%22">Black BE</searchLink>; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute.; Graduate Program in Biochemistry, Biophysics, Chemical Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140-6059 USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2024 May 20. <i>Date of Electronic Publication: </i>2024 May 20.
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        Value: 10.1101/2024.05.20.594972
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