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Engineered Exosomes Containing microRNA-29b-2 and Targeting the Somatostatin Receptor Reduce Presenilin 1 Expression and Decrease the β-Amyloid Accumulation in the Brains of Mice with Alzheimer's Disease.

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Title: Engineered Exosomes Containing microRNA-29b-2 and Targeting the Somatostatin Receptor Reduce Presenilin 1 Expression and Decrease the β-Amyloid Accumulation in the Brains of Mice with Alzheimer's Disease.
Authors: Lin EY; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan., Hsu SX; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan., Wu BH; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan., Deng YC; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.; Everfront Biotech Inc, Taipei, Taiwan., Wuli W; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan., Li YS; Everfront Biotech Inc, Taipei, Taiwan., Lee JH; Everfront Biotech Inc, Taipei, Taiwan., Lin SZ; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Neurosurgery, Hualien Tzu Chi Hospital, Hualien, Taiwan., Harn HJ; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Pathology, Hualien Tzu Chi Hospital, Hualien, Taiwan., Chiou TW; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.
Source: International journal of nanomedicine [Int J Nanomedicine] 2024 May 29; Vol. 19, pp. 4977-4994. Date of Electronic Publication: 2024 May 29 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineered Exosomes Containing microRNA-29b-2 and Targeting the Somatostatin Receptor Reduce Presenilin 1 Expression and Decrease the β-Amyloid Accumulation in the Brains of Mice with Alzheimer's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Lin+EY%22">Lin EY</searchLink>; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+SX%22">Hsu SX</searchLink>; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+BH%22">Wu BH</searchLink>; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Deng+YC%22">Deng YC</searchLink>; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.; Everfront Biotech Inc, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wuli+W%22">Wuli W</searchLink>; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+YS%22">Li YS</searchLink>; Everfront Biotech Inc, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Everfront Biotech Inc, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SZ%22">Lin SZ</searchLink>; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Neurosurgery, Hualien Tzu Chi Hospital, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Harn+HJ%22">Harn HJ</searchLink>; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Department of Pathology, Hualien Tzu Chi Hospital, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiou+TW%22">Chiou TW</searchLink>; Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101263847%22">International journal of nanomedicine</searchLink> [Int J Nanomedicine] 2024 May 29; Vol. 19, pp. 4977-4994. <i>Date of Electronic Publication: </i>2024 May 29 (<i>Print Publication: </i>2024).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22DOVE+Medical+Press%22">DOVE Medical Press </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>101263847 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1178-2013 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211769114%22">11769114 </searchLink><i>NLM ISO Abbreviation: </i>Int J Nanomedicine <i>Subsets: </i>MEDLINE
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        Value: 10.2147/IJN.S442876
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        Text: English
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      – TitleFull: Engineered Exosomes Containing microRNA-29b-2 and Targeting the Somatostatin Receptor Reduce Presenilin 1 Expression and Decrease the β-Amyloid Accumulation in the Brains of Mice with Alzheimer's Disease.
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              Text: 2024 May 29
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