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Safety and efficacy outcomes of early cessation of anti-PD1 therapy in patients 80 years or older: A retrospective cohort study.

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Title: Safety and efficacy outcomes of early cessation of anti-PD1 therapy in patients 80 years or older: A retrospective cohort study.
Authors: Fletcher K; Vanderbilt University School of Medicine, Nashville, USA. Electronic address: kylie.a.fletcher@vanderbilt.edu., Cortellini A; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128, Roma, Italy; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom., Ganta T; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kankaria R; Vanderbilt University School of Medicine, Nashville, USA., Song H; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Ye F; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Irlmeier R; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Debnath N; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Saeed A; Division of Hematology & Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Radford M; University of Iowa Healthcare, Iowa City, IA, USA., Alahmadi A; Case Western Reserve University, Division of Hematology & Oncology, Cleveland, OH, USA; Ohio State University, The James Comprehensive Cancer Center, Columbus., Diamond A; Case Western Reserve University, Division of Hematology & Oncology, Cleveland, OH, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Hoimes C; Case Western Reserve University, Division of Hematology & Oncology, Cleveland, OH, USA; Duke Cancer Institute, Duke University, Durham, NC, USA., Presley CJ; Ohio State University, The James Comprehensive Cancer Center, Columbus., Owen DH; Ohio State University, The James Comprehensive Cancer Center, Columbus., Abou Alaiwi S; Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, USA., Nassar AH; Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, USA., Lamberti G; Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy., Perrone F; Medical Oncology Unit, University Hospital of Parma and Medicine and Surgery Department, University of Parma, Parma, Italy., Buti S; Medical Oncology Unit, University Hospital of Parma and Medicine and Surgery Department, University of Parma, Parma, Italy., Giusti R; Medical Oncology Unit, Azienda Ospedaliero Universitaria Sant'Andrea, Rome, Italy., Filetti M; Phase 1 Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy., Vanella V; Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy., Mallardo D; Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy., Sussman TA; Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Galetta D; IRCCS Istituto Tumori Giovanni Paolo II, Medical Thoracic Oncology Unit, Bari, Italy., Kalofonou F; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Daniels E; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Ascierto PA; Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy., Pinato DJ; Department of Surgery and Cancer, Imperial College London, London, United Kingdom; Department of Translational Medicine, University of Piemonte Orientale 'A. Avogadro', Novara, Italy., Nebhan C; Intermountain Health, Murray UT, USA., Berg S; Dana-Farber Cancer Institute, Boston, MA, USA., Choueiri TK; Dana-Farber Cancer Institute, Boston, MA, USA., Marron TU; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang Y; The University of Texas MD Anderson Cancer Center, Houston., Naqash AR; Medical Oncology/TSET Phase 1 Program, Stephenson Cancer Center, University of Oklahoma, Oklahoma City, USA., Johnson DB; Department of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: douglas.b.johnson@vumc.org.
Source: Cancer letters [Cancer Lett] 2024 Aug 01; Vol. 596, pp. 217001. Date of Electronic Publication: 2024 Jun 03.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and efficacy outcomes of early cessation of anti-PD1 therapy in patients 80 years or older: A retrospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Fletcher+K%22">Fletcher K</searchLink>; Vanderbilt University School of Medicine, Nashville, USA. Electronic address: kylie.a.fletcher@vanderbilt.edu.<br /><searchLink fieldCode="AU" term="%22Cortellini+A%22">Cortellini A</searchLink>; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128, Roma, Italy; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ganta+T%22">Ganta T</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kankaria+R%22">Kankaria R</searchLink>; Vanderbilt University School of Medicine, Nashville, USA.<br /><searchLink fieldCode="AU" term="%22Song+H%22">Song H</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Ye+F%22">Ye F</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Irlmeier+R%22">Irlmeier R</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Debnath+N%22">Debnath N</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Saeed+A%22">Saeed A</searchLink>; Division of Hematology & Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Radford+M%22">Radford M</searchLink>; University of Iowa Healthcare, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Alahmadi+A%22">Alahmadi A</searchLink>; Case Western Reserve University, Division of Hematology & Oncology, Cleveland, OH, USA; Ohio State University, The James Comprehensive Cancer Center, Columbus.<br /><searchLink fieldCode="AU" term="%22Diamond+A%22">Diamond A</searchLink>; Case Western Reserve University, Division of Hematology & Oncology, Cleveland, OH, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hoimes+C%22">Hoimes C</searchLink>; Case Western Reserve University, Division of Hematology & Oncology, Cleveland, OH, USA; Duke Cancer Institute, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Presley+CJ%22">Presley CJ</searchLink>; Ohio State University, The James Comprehensive Cancer Center, Columbus.<br /><searchLink fieldCode="AU" term="%22Owen+DH%22">Owen DH</searchLink>; Ohio State University, The James Comprehensive Cancer Center, Columbus.<br /><searchLink fieldCode="AU" term="%22Abou+Alaiwi+S%22">Abou Alaiwi S</searchLink>; Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Nassar+AH%22">Nassar AH</searchLink>; Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Lamberti+G%22">Lamberti G</searchLink>; Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Perrone+F%22">Perrone F</searchLink>; Medical Oncology Unit, University Hospital of Parma and Medicine and Surgery Department, University of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Buti+S%22">Buti S</searchLink>; Medical Oncology Unit, University Hospital of Parma and Medicine and Surgery Department, University of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Giusti+R%22">Giusti R</searchLink>; Medical Oncology Unit, Azienda Ospedaliero Universitaria Sant'Andrea, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Filetti+M%22">Filetti M</searchLink>; Phase 1 Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vanella+V%22">Vanella V</searchLink>; Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Mallardo+D%22">Mallardo D</searchLink>; Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Sussman+TA%22">Sussman TA</searchLink>; Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Galetta+D%22">Galetta D</searchLink>; IRCCS Istituto Tumori Giovanni Paolo II, Medical Thoracic Oncology Unit, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Kalofonou+F%22">Kalofonou F</searchLink>; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Daniels+E%22">Daniels E</searchLink>; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ascierto+PA%22">Ascierto PA</searchLink>; Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Pinato+DJ%22">Pinato DJ</searchLink>; Department of Surgery and Cancer, Imperial College London, London, United Kingdom; Department of Translational Medicine, University of Piemonte Orientale 'A. Avogadro', Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Nebhan+C%22">Nebhan C</searchLink>; Intermountain Health, Murray UT, USA.<br /><searchLink fieldCode="AU" term="%22Berg+S%22">Berg S</searchLink>; Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Choueiri+TK%22">Choueiri TK</searchLink>; Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Marron+TU%22">Marron TU</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; The University of Texas MD Anderson Cancer Center, Houston.<br /><searchLink fieldCode="AU" term="%22Naqash+AR%22">Naqash AR</searchLink>; Medical Oncology/TSET Phase 1 Program, Stephenson Cancer Center, University of Oklahoma, Oklahoma City, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+DB%22">Johnson DB</searchLink>; Department of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: douglas.b.johnson@vumc.org.
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  Data: <searchLink fieldCode="JN" term="%227600053%22">Cancer letters</searchLink> [Cancer Lett] 2024 Aug 01; Vol. 596, pp. 217001. <i>Date of Electronic Publication: </i>2024 Jun 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ireland%22">Elsevier Science Ireland </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>7600053 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7980 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203043835%22">03043835 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Lett <i>Subsets: </i>MEDLINE
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