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Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.

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Title: Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
Authors: Pettersson M; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Johnson DS; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Humphrey JM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Am Ende CW; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Butler TW; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Dorff PH; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Efremov IV; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Evrard E; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Green ME; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Helal CJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Kauffman GW; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Mullins PB; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Navaratnam T; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., O'Donnell CJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., O'Sullivan TJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Patel NC; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Stepan AF; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Stiff CM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Subramanyam C; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Trapa P; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Tran TP; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Vetelino BC; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Yang E; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Xie L; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Pustilnik LR; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Steyn SJ; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Wood KM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Bales KR; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Hajos-Korcsok E; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Verhoest PR; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Jun 27; Vol. 67 (12), pp. 10248-10262. Date of Electronic Publication: 2024 Jun 07.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Pettersson+M%22">Pettersson M</searchLink>; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Johnson+DS%22">Johnson DS</searchLink>; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Humphrey+JM%22">Humphrey JM</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Am+Ende+CW%22">Am Ende CW</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Butler+TW%22">Butler TW</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Dorff+PH%22">Dorff PH</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Efremov+IV%22">Efremov IV</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Evrard+E%22">Evrard E</searchLink>; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Green+ME%22">Green ME</searchLink>; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Helal+CJ%22">Helal CJ</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Kauffman+GW%22">Kauffman GW</searchLink>; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Mullins+PB%22">Mullins PB</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Navaratnam+T%22">Navaratnam T</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Jun 27; Vol. 67 (12), pp. 10248-10262. <i>Date of Electronic Publication: </i>2024 Jun 07.
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        Value: 10.1021/acs.jmedchem.4c00580
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