Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
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| Title: | Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease. |
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| Authors: | Pettersson M; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Johnson DS; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Humphrey JM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Am Ende CW; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Butler TW; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Dorff PH; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Efremov IV; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Evrard E; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Green ME; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Helal CJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Kauffman GW; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Mullins PB; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Navaratnam T; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., O'Donnell CJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., O'Sullivan TJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Patel NC; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Stepan AF; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Stiff CM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Subramanyam C; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Trapa P; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Tran TP; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Vetelino BC; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Yang E; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Xie L; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Pustilnik LR; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Steyn SJ; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Wood KM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Bales KR; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Hajos-Korcsok E; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Verhoest PR; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2024 Jun 27; Vol. 67 (12), pp. 10248-10262. Date of Electronic Publication: 2024 Jun 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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