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A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.

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Title: A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.
Authors: Ortega-Molina A; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. aortega@cbm.csic.es.; Metabolism in cancer and aging Laboratory, Immune System Development And Function Department, Centro de Biología Molecular Severo Ochoa (CBM), Madrid, Spain. aortega@cbm.csic.es., Lebrero-Fernández C; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Metabolism in cancer and aging Laboratory, Immune System Development And Function Department, Centro de Biología Molecular Severo Ochoa (CBM), Madrid, Spain., Sanz A; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Calvo-Rubio M; Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA., Deleyto-Seldas N; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., de Prado-Rivas L; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Plata-Gómez AB; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Fernández-Florido E; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., González-García P; Histopathology Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Vivas-García Y; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Sánchez García E; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Graña-Castro O; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Institute of Applied Molecular Medicine (IMMA-Nemesio Díez), Department of Basic Medical Sciences, School of Medicine, San Pablo-CEU University, CEU Universities, Boadilla del Monte, Madrid, Spain., Price NL; Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA., Aroca-Crevillén A; Cardiovascular Regeneration Program, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain., Caleiras E; Histopathology Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Monleón D; Department of Pathology, University of Valencia, Valencia, Spain; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), Institute of Health Research-INCLIVA, Valencia, Spain., Borrás C; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), MiniAging Research Group, Institute of Health Research-INCLIVA, Valencia, Spain., Casanova-Acebes M; Cancer Immunity Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., de Cabo R; Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA., Efeyan A; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. aefeyan@cnio.es.
Source: Nature aging [Nat Aging] 2024 Aug; Vol. 4 (8), pp. 1102-1120. Date of Electronic Publication: 2024 Jun 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.
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  Data: <searchLink fieldCode="AU" term="%22Ortega-Molina+A%22">Ortega-Molina A</searchLink>; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. aortega@cbm.csic.es.; Metabolism in cancer and aging Laboratory, Immune System Development And Function Department, Centro de Biología Molecular Severo Ochoa (CBM), Madrid, Spain. aortega@cbm.csic.es.<br /><searchLink fieldCode="AU" term="%22Lebrero-Fernández+C%22">Lebrero-Fernández C</searchLink>; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Metabolism in cancer and aging Laboratory, Immune System Development And Function Department, Centro de Biología Molecular Severo Ochoa (CBM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz+A%22">Sanz A</searchLink>; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Calvo-Rubio+M%22">Calvo-Rubio M</searchLink>; Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Deleyto-Seldas+N%22">Deleyto-Seldas N</searchLink>; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22de+Prado-Rivas+L%22">de Prado-Rivas L</searchLink>; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Plata-Gómez+AB%22">Plata-Gómez AB</searchLink>; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Florido+E%22">Fernández-Florido E</searchLink>; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22González-García+P%22">González-García P</searchLink>; Histopathology Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vivas-García+Y%22">Vivas-García Y</searchLink>; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez+García+E%22">Sánchez García E</searchLink>; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Graña-Castro+O%22">Graña-Castro O</searchLink>; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Institute of Applied Molecular Medicine (IMMA-Nemesio Díez), Department of Basic Medical Sciences, School of Medicine, San Pablo-CEU University, CEU Universities, Boadilla del Monte, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Price+NL%22">Price NL</searchLink>; Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Aroca-Crevillén+A%22">Aroca-Crevillén A</searchLink>; Cardiovascular Regeneration Program, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Caleiras+E%22">Caleiras E</searchLink>; Histopathology Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Monleón+D%22">Monleón D</searchLink>; Department of Pathology, University of Valencia, Valencia, Spain; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), Institute of Health Research-INCLIVA, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Borrás+C%22">Borrás C</searchLink>; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), MiniAging Research Group, Institute of Health Research-INCLIVA, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Casanova-Acebes+M%22">Casanova-Acebes M</searchLink>; Cancer Immunity Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22de+Cabo+R%22">de Cabo R</searchLink>; Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Efeyan+A%22">Efeyan A</searchLink>; Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. aefeyan@cnio.es.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2024 Aug; Vol. 4 (8), pp. 1102-1120. <i>Date of Electronic Publication: </i>2024 Jun 07.
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