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Generating universal anti-CD19 CAR T cells with a defined memory phenotype by CRISPR/Cas9 editing and safety evaluation of the transcriptome.

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Title: Generating universal anti-CD19 CAR T cells with a defined memory phenotype by CRISPR/Cas9 editing and safety evaluation of the transcriptome.
Authors: Pavlovic K; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.; Cell Therapy Group, Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain., Carmona-Luque M; Cell Therapy Group, Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain., Corsi GI; Department of Veterinary and Animal Sciences, Center for non-coding RNA in Technology and Health, University of Copenhagen, Thorvaldsensvej, Denmark., Maldonado-Pérez N; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain., Molina-Estevez FJ; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain., Peralbo-Santaella E; Flow Cytometry Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain., Cortijo-Gutiérrez M; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain., Justicia-Lirio P; LentiStem Biotech, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain., Tristán-Manzano M; LentiStem Biotech, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain., Ronco-Díaz V; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain., Ballesteros-Ribelles A; Cell Therapy Group, Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain., Millán-López A; Cell Therapy Group, Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain., Heredia-Velázquez P; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.; Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain., Fuster-García C; Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Cathomen T; Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Seemann SE; Department of Veterinary and Animal Sciences, Center for non-coding RNA in Technology and Health, University of Copenhagen, Thorvaldsensvej, Denmark., Gorodkin J; Department of Veterinary and Animal Sciences, Center for non-coding RNA in Technology and Health, University of Copenhagen, Thorvaldsensvej, Denmark., Martin F; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain.; Biosanitary Research Institute of Granada (ibs.GRANADA), University of Granada, Granada, Spain., Herrera C; Cell Therapy Group, Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; Department of Hematology, Reina Sofia University Hospital, Cordoba, Spain.; Department of Medical and Surgical Sciences, School of Medicine, University of Cordoba, Cordoba, Spain., Benabdellah K; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.
Source: Frontiers in immunology [Front Immunol] 2024 May 29; Vol. 15, pp. 1401683. Date of Electronic Publication: 2024 May 29 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Generating universal anti-CD19 CAR T cells with a defined memory phenotype by CRISPR/Cas9 editing and safety evaluation of the transcriptome.
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  Data: <searchLink fieldCode="AU" term="%22Pavlovic+K%22">Pavlovic K</searchLink>; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.; Cell Therapy Group, Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.<br /><searchLink fieldCode="AU" term="%22Carmona-Luque+M%22">Carmona-Luque M</searchLink>; Cell Therapy Group, Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.<br /><searchLink fieldCode="AU" term="%22Corsi+GI%22">Corsi GI</searchLink>; Department of Veterinary and Animal Sciences, Center for non-coding RNA in Technology and Health, University of Copenhagen, Thorvaldsensvej, Denmark.<br /><searchLink fieldCode="AU" term="%22Maldonado-Pérez+N%22">Maldonado-Pérez N</searchLink>; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Molina-Estevez+FJ%22">Molina-Estevez FJ</searchLink>; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Peralbo-Santaella+E%22">Peralbo-Santaella E</searchLink>; Flow Cytometry Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain.<br /><searchLink fieldCode="AU" term="%22Cortijo-Gutiérrez+M%22">Cortijo-Gutiérrez M</searchLink>; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Justicia-Lirio+P%22">Justicia-Lirio P</searchLink>; LentiStem Biotech, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Tristán-Manzano+M%22">Tristán-Manzano M</searchLink>; LentiStem Biotech, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Ronco-Díaz+V%22">Ronco-Díaz V</searchLink>; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Ballesteros-Ribelles+A%22">Ballesteros-Ribelles A</searchLink>; Cell Therapy Group, Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.<br /><searchLink fieldCode="AU" term="%22Millán-López+A%22">Millán-López A</searchLink>; Cell Therapy Group, Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.<br /><searchLink fieldCode="AU" term="%22Heredia-Velázquez+P%22">Heredia-Velázquez P</searchLink>; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.; Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Fuster-García+C%22">Fuster-García C</searchLink>; Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Cathomen+T%22">Cathomen T</searchLink>; Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Seemann+SE%22">Seemann SE</searchLink>; Department of Veterinary and Animal Sciences, Center for non-coding RNA in Technology and Health, University of Copenhagen, Thorvaldsensvej, Denmark.<br /><searchLink fieldCode="AU" term="%22Gorodkin+J%22">Gorodkin J</searchLink>; Department of Veterinary and Animal Sciences, Center for non-coding RNA in Technology and Health, University of Copenhagen, Thorvaldsensvej, Denmark.<br /><searchLink fieldCode="AU" term="%22Martin+F%22">Martin F</searchLink>; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain.; Biosanitary Research Institute of Granada (ibs.GRANADA), University of Granada, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Herrera+C%22">Herrera C</searchLink>; Cell Therapy Group, Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), Cordoba, Spain.; Department of Hematology, Reina Sofia University Hospital, Cordoba, Spain.; Department of Medical and Surgical Sciences, School of Medicine, University of Cordoba, Cordoba, Spain.<br /><searchLink fieldCode="AU" term="%22Benabdellah+K%22">Benabdellah K</searchLink>; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.
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