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Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti-SARS-CoV-2 Activity.

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Title: Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti-SARS-CoV-2 Activity.
Authors: Gege C; Immunic AG, Lochhamer Schlag 21, 82166, Gräfelfing, Germany., Hahn F; Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany., Wangen C; Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany., Häge S; Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany., Herrmann A; Immunic AG, Lochhamer Schlag 21, 82166, Gräfelfing, Germany., Uhlig N; Department of Vaccines and Infection Models, Unit Preclinical Validation, Fraunhofer-Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103, Leipzig, Germany., Eberlein V; Department of Vaccines and Infection Models, Unit Preclinical Validation, Fraunhofer-Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103, Leipzig, Germany., Issmail L; Department of Vaccines and Infection Models, Unit Preclinical Validation, Fraunhofer-Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103, Leipzig, Germany., Klopfleisch R; Institute of Veterinary Pathology, Freie Universität Berlin, Robert-von-Ostertag-Str. 15, 14163, Berlin, Germany., Grunwald T; Department of Vaccines and Infection Models, Unit Preclinical Validation, Fraunhofer-Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103, Leipzig, Germany., Marschall M; Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany., Kohlhof H; Immunic AG, Lochhamer Schlag 21, 82166, Gräfelfing, Germany., Vitt D; Immunic AG, Lochhamer Schlag 21, 82166, Gräfelfing, Germany.
Source: ChemMedChem [ChemMedChem] 2024 Oct 01; Vol. 19 (19), pp. e202400292. Date of Electronic Publication: 2024 Aug 06.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti-SARS-CoV-2 Activity.
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  Data: <searchLink fieldCode="AU" term="%22Gege+C%22">Gege C</searchLink>; Immunic AG, Lochhamer Schlag 21, 82166, Gräfelfing, Germany.<br /><searchLink fieldCode="AU" term="%22Hahn+F%22">Hahn F</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Wangen+C%22">Wangen C</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Häge+S%22">Häge S</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Herrmann+A%22">Herrmann A</searchLink>; Immunic AG, Lochhamer Schlag 21, 82166, Gräfelfing, Germany.<br /><searchLink fieldCode="AU" term="%22Uhlig+N%22">Uhlig N</searchLink>; Department of Vaccines and Infection Models, Unit Preclinical Validation, Fraunhofer-Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Eberlein+V%22">Eberlein V</searchLink>; Department of Vaccines and Infection Models, Unit Preclinical Validation, Fraunhofer-Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Issmail+L%22">Issmail L</searchLink>; Department of Vaccines and Infection Models, Unit Preclinical Validation, Fraunhofer-Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Klopfleisch+R%22">Klopfleisch R</searchLink>; Institute of Veterinary Pathology, Freie Universität Berlin, Robert-von-Ostertag-Str. 15, 14163, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Grunwald+T%22">Grunwald T</searchLink>; Department of Vaccines and Infection Models, Unit Preclinical Validation, Fraunhofer-Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Marschall+M%22">Marschall M</searchLink>; Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kohlhof+H%22">Kohlhof H</searchLink>; Immunic AG, Lochhamer Schlag 21, 82166, Gräfelfing, Germany.<br /><searchLink fieldCode="AU" term="%22Vitt+D%22">Vitt D</searchLink>; Immunic AG, Lochhamer Schlag 21, 82166, Gräfelfing, Germany.
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