Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS.

Saved in:
Bibliographic Details
Title: Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS.
Authors: Chatterjee M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Özdemir S; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Genetics, Atatürk University, Erzurum, Turkey., Fritz C; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Möbius W; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany., Kleineidam L; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany., Mandelkow E; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany., Biernat J; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany., Doğdu C; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Peters O; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Cosma NC; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Wang X; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Schneider LS; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Department of Psychiatry and Psychotherapy, Technical University of Munich School of Medicine, Munich, Germany.; University of Edinburgh and UK DRI, Edinburgh, UK., Spruth E; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany., Kühn AA; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Krause P; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Klockgether T; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Vogt IR; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Kimmich O; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Spottke A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Hoffmann DC; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Fliessbach K; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany., Miklitz C; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany., McCormick C; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany., Weydt P; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Falkenburger B; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Brandt M; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Guenther R; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Dinter E; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Wiltfang J; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany.; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal., Hansen N; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany., Bähr M; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department of Neurology, University Medical Center, Georg August University, Göttingen, Germany.; Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), University Medical Center Göttingen, Göttingen, Germany., Zerr I; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department of Neurology, University Medical Center, Georg August University, Göttingen, Germany., Flöel A; Department of Neurology, University Medicine Greifswald, Greifswald, Germany.; German Centre for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany., Nestor PJ; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Queensland Brain Institute, University of Queensland and Mater Public Hospital, Brisbane, Queensland, Australia., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany.; Institute of Cognitive Neuroscience, University College London, London, UK., Glanz W; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany.; Clinic for Neurology, University Hospital Magdeburg, Magdeburg, Germany., Incesoy E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany.; Department of Psychiatry and Psychotherapy, University Hospital Magdeburg, Magdeburg, Germany., Bürger K; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany., Janowitz D; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany., Perneczky R; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK., Rauchmann BS; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Department of Neuroradiology, University Hospital LMU, Munich, Germany.; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Hopfner F; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany., Wagemann O; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany., Levin J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany., Teipel S; German Centre for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Kilimann I; German Centre for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Goerss D; German Centre for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany., Prudlo J; German Centre for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Department of Neurology, Rostock University Medical Centre, Rostock, Germany., Gasser T; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany., Brockmann K; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany., Mengel D; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany., Zimmermann M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany., Synofzik M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany., Wilke C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany., Selma-González J; Sant Pau Memory Unit, Department of Neurology, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Motor Neuron Disease Clinic, Neuromuscular Diseases Unit, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Turon-Sans J; Motor Neuron Disease Clinic, Neuromuscular Diseases Unit, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain., Santos-Santos MA; Sant Pau Memory Unit, Department of Neurology, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Alcolea D; Sant Pau Memory Unit, Department of Neurology, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Rubio-Guerra S; Sant Pau Memory Unit, Department of Neurology, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Fortea J; Sant Pau Memory Unit, Department of Neurology, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Carbayo Á; Motor Neuron Disease Clinic, Neuromuscular Diseases Unit, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain., Lleó A; Sant Pau Memory Unit, Department of Neurology, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Rojas-García R; Motor Neuron Disease Clinic, Neuromuscular Diseases Unit, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain., Illán-Gala I; Sant Pau Memory Unit, Department of Neurology, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Wagner M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany., Frommann I; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany., Roeske S; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Bertram L; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Heneka MT; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg.; Department of Infectious Diseases and Immunology, University of Massachussetss Medical School, North Worcester, MA, USA., Brosseron F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Ramirez A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry, University of Cologne, Cologne, Germany.; Department of Psychiatry, Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA., Schmid M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany., Beschorner R; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neuropathology, University of Tübingen, Tübingen, Germany., Halle A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neuropathology, University Hospital Bonn, Bonn, Germany., Herms J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.; Center for Neuropathology and Prion Research, LMU Munich, Munich, Germany., Neumann M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neuropathology, University of Tübingen, Tübingen, Germany., Barthélemy NR; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Tracy Family SILQ Center for Neurodegenerative Biology, St. Louis, MO, USA., Bateman RJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Tracy Family SILQ Center for Neurodegenerative Biology, St. Louis, MO, USA., Rizzu P; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Heutink P; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Dols-Icardo O; Sant Pau Memory Unit, Department of Neurology, Institut de Recerca Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Höglinger G; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.; Department of Neurology, University Hospital of Munich, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany., Hermann A; German Centre for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Translational Neurodegeneration Section 'Albrecht Kossel' and Center for Transdisciplinary Neurosciences, University Medical Center Rostock, Rostock, Germany., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. anja.schneider@dzne.de.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany. anja.schneider@dzne.de.
Source: Nature medicine [Nat Med] 2024 Jun; Vol. 30 (6), pp. 1771-1783. Date of Electronic Publication: 2024 Jun 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-024-02937-4