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Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age.

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Title: Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age.
Authors: Molière A; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland., Park JYC; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland., Goyala A; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland., Vayndorf EM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195-7470, USA., Zhang B; Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK., Hsiung KC; Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK., Jung Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, South Korea., Kwon S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, South Korea., Statzer C; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland., Meyer D; Institute for Genome Stability in Aging and Disease, Medical Faculty, University Hospital and University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany., Nguyen R; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195-7470, USA., Chadwick J; The Babraham Institute, Cambridge, UK., Thompson MA; The Babraham Institute, Cambridge, UK., Schumacher B; Institute for Genome Stability in Aging and Disease, Medical Faculty, University Hospital and University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany., Lee SV; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, South Korea., Essmann CL; Bioinformatics and Molecular Genetics, Institute of Biology III, Faculty of Biology, Albert-Ludwigs-University Freiburg, 79108, Freiburg, Germany., MacArthur MR; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08540, USA., Kaeberlein M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195-7470, USA., David D; The Babraham Institute, Cambridge, UK., Gems D; Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK., Ewald CY; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland. collin-ewald@ethz.ch.
Source: GeroScience [Geroscience] 2024 Oct; Vol. 46 (5), pp. 5015-5036. Date of Electronic Publication: 2024 Jun 20.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age.
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  Data: <searchLink fieldCode="AU" term="%22Molière+A%22">Molière A</searchLink>; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland.<br /><searchLink fieldCode="AU" term="%22Park+JYC%22">Park JYC</searchLink>; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland.<br /><searchLink fieldCode="AU" term="%22Goyala+A%22">Goyala A</searchLink>; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vayndorf+EM%22">Vayndorf EM</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195-7470, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hsiung+KC%22">Hsiung KC</searchLink>; Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Jung+Y%22">Jung Y</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, South Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+S%22">Kwon S</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, South Korea.<br /><searchLink fieldCode="AU" term="%22Statzer+C%22">Statzer C</searchLink>; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland.<br /><searchLink fieldCode="AU" term="%22Meyer+D%22">Meyer D</searchLink>; Institute for Genome Stability in Aging and Disease, Medical Faculty, University Hospital and University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Nguyen+R%22">Nguyen R</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195-7470, USA.<br /><searchLink fieldCode="AU" term="%22Chadwick+J%22">Chadwick J</searchLink>; The Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Thompson+MA%22">Thompson MA</searchLink>; The Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Schumacher+B%22">Schumacher B</searchLink>; Institute for Genome Stability in Aging and Disease, Medical Faculty, University Hospital and University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Lee+SV%22">Lee SV</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, South Korea.<br /><searchLink fieldCode="AU" term="%22Essmann+CL%22">Essmann CL</searchLink>; Bioinformatics and Molecular Genetics, Institute of Biology III, Faculty of Biology, Albert-Ludwigs-University Freiburg, 79108, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22MacArthur+MR%22">MacArthur MR</searchLink>; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08540, USA.<br /><searchLink fieldCode="AU" term="%22Kaeberlein+M%22">Kaeberlein M</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195-7470, USA.<br /><searchLink fieldCode="AU" term="%22David+D%22">David D</searchLink>; The Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gems+D%22">Gems D</searchLink>; Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ewald+CY%22">Ewald CY</searchLink>; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland. collin-ewald@ethz.ch.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101686284 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2509-2723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225092723%22">25092723 </searchLink><i>NLM ISO Abbreviation: </i>Geroscience <i>Subsets: </i>MEDLINE
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