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Optimization of diastereomeric dihydropyridines as antimalarials.

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Title: Optimization of diastereomeric dihydropyridines as antimalarials.
Authors: Van Horn KS; Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL, 33620, United States; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States. Electronic address: k.vanhorn@neu.edu., Zhao Y; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States., Parvatkar PT; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States., Maier J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, United States., Mutka T; Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL, 33612, United States., Lacrue A; Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL, 33612, United States., Brockmeier F; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States., Ebert D; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, 94158, United States., Wu W; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, 94158, United States., Casandra DR; Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL, 33612, United States., Namelikonda N; Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL, 33620, United States., Yacoub J; Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL, 33620, United States., Sigal M; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, United States., Knapp S; Department of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, 610 Taylor Road, Piscataway, NJ, 08854, United States., Floyd D; Department of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, 610 Taylor Road, Piscataway, NJ, 08854, United States., Waterson D; Medicines for Malaria Venture, 20, Route de Pré-Bois, P.O. Box 1826, 1215, Geneva, 15, Switzerland., Burrows JN; Medicines for Malaria Venture, 20, Route de Pré-Bois, P.O. Box 1826, 1215, Geneva, 15, Switzerland., Duffy J; Medicines for Malaria Venture, 20, Route de Pré-Bois, P.O. Box 1826, 1215, Geneva, 15, Switzerland., DeRisi JL; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, 94158, United States; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, United States., Kyle DE; Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL, 33612, United States; Center for Tropical & Emerging Global Diseases, University of Georgia, Athens, GA, 30602, United States., Guy RK; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, United States; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40506, United States., Manetsch R; Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL, 33620, United States; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States; Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States. Electronic address: r.manetsch@northeastern.edu.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116599. Date of Electronic Publication: 2024 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
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  Data: Optimization of diastereomeric dihydropyridines as antimalarials.
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  Data: <searchLink fieldCode="AU" term="%22Van+Horn+KS%22">Van Horn KS</searchLink>; Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL, 33620, United States; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States. Electronic address: k.vanhorn@neu.edu.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States.<br /><searchLink fieldCode="AU" term="%22Parvatkar+PT%22">Parvatkar PT</searchLink>; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States.<br /><searchLink fieldCode="AU" term="%22Maier+J%22">Maier J</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, United States.<br /><searchLink fieldCode="AU" term="%22Mutka+T%22">Mutka T</searchLink>; Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL, 33612, United States.<br /><searchLink fieldCode="AU" term="%22Lacrue+A%22">Lacrue A</searchLink>; Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL, 33612, United States.<br /><searchLink fieldCode="AU" term="%22Brockmeier+F%22">Brockmeier F</searchLink>; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States.<br /><searchLink fieldCode="AU" term="%22Ebert+D%22">Ebert D</searchLink>; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, 94158, United States.<br /><searchLink fieldCode="AU" term="%22Wu+W%22">Wu W</searchLink>; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, 94158, United States.<br /><searchLink fieldCode="AU" term="%22Casandra+DR%22">Casandra DR</searchLink>; Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL, 33612, United States.<br /><searchLink fieldCode="AU" term="%22Namelikonda+N%22">Namelikonda N</searchLink>; Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL, 33620, United States.<br /><searchLink fieldCode="AU" term="%22Yacoub+J%22">Yacoub J</searchLink>; Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL, 33620, United States.<br /><searchLink fieldCode="AU" term="%22Sigal+M%22">Sigal M</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, United States.<br /><searchLink fieldCode="AU" term="%22Knapp+S%22">Knapp S</searchLink>; Department of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, 610 Taylor Road, Piscataway, NJ, 08854, United States.<br /><searchLink fieldCode="AU" term="%22Floyd+D%22">Floyd D</searchLink>; Department of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, 610 Taylor Road, Piscataway, NJ, 08854, United States.<br /><searchLink fieldCode="AU" term="%22Waterson+D%22">Waterson D</searchLink>; Medicines for Malaria Venture, 20, Route de Pré-Bois, P.O. Box 1826, 1215, Geneva, 15, Switzerland.<br /><searchLink fieldCode="AU" term="%22Burrows+JN%22">Burrows JN</searchLink>; Medicines for Malaria Venture, 20, Route de Pré-Bois, P.O. Box 1826, 1215, Geneva, 15, Switzerland.<br /><searchLink fieldCode="AU" term="%22Duffy+J%22">Duffy J</searchLink>; Medicines for Malaria Venture, 20, Route de Pré-Bois, P.O. Box 1826, 1215, Geneva, 15, Switzerland.<br /><searchLink fieldCode="AU" term="%22DeRisi+JL%22">DeRisi JL</searchLink>; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, 94158, United States; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, United States.<br /><searchLink fieldCode="AU" term="%22Kyle+DE%22">Kyle DE</searchLink>; Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL, 33612, United States; Center for Tropical & Emerging Global Diseases, University of Georgia, Athens, GA, 30602, United States.<br /><searchLink fieldCode="AU" term="%22Guy+RK%22">Guy RK</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, United States; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40506, United States.<br /><searchLink fieldCode="AU" term="%22Manetsch+R%22">Manetsch R</searchLink>; Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL, 33620, United States; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States; Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, United States. Electronic address: r.manetsch@northeastern.edu.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116599. <i>Date of Electronic Publication: </i>2024 Jun 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
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