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Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.

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Title: Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.
Authors: Sorets AG; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Schwensen KR; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Francini N; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Kjar A; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Abdulrahman AM; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Shostak A; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Katdare KA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA., Schoch KM; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Cowell RP; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Park JC; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Ligocki AP; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Ford WT; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Ventura-Antunes L; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Hoogenboezem EN; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Prusky A; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Castleberry M; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Michell DL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Miller TM; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Vickers KC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Schrag MS; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Duvall CL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Lippmann ES; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 07. Date of Electronic Publication: 2024 Sep 07.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.
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