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Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants.

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Title: Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants.
Authors: Capener JL; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Vasta JD; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Katis VL; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK., Michaud A; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Beck MT; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Daglish SCD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Cohen-Kedar S; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Barda ES; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Howell S; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dotan I; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Robers MB; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Axtman AD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Bashore FM; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 13. Date of Electronic Publication: 2024 Jun 13.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Capener+JL%22">Capener JL</searchLink>; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Vasta+JD%22">Vasta JD</searchLink>; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA.<br /><searchLink fieldCode="AU" term="%22Katis+VL%22">Katis VL</searchLink>; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.<br /><searchLink fieldCode="AU" term="%22Michaud+A%22">Michaud A</searchLink>; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA.<br /><searchLink fieldCode="AU" term="%22Beck+MT%22">Beck MT</searchLink>; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA.<br /><searchLink fieldCode="AU" term="%22Daglish+SCD%22">Daglish SCD</searchLink>; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Cohen-Kedar+S%22">Cohen-Kedar S</searchLink>; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Barda+ES%22">Barda ES</searchLink>; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Howell+S%22">Howell S</searchLink>; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Dotan+I%22">Dotan I</searchLink>; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Robers+MB%22">Robers MB</searchLink>; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA.<br /><searchLink fieldCode="AU" term="%22Axtman+AD%22">Axtman AD</searchLink>; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Bashore+FM%22">Bashore FM</searchLink>; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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