A randomized, open-label two-period crossover pilot study to evaluate the relative bioavailability in the fed state of atovaquone-proguanil (Atoguanil™) versus atovaquone-proguanil hydrochloride (Malarone®) in healthy adult participants.
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| Title: | A randomized, open-label two-period crossover pilot study to evaluate the relative bioavailability in the fed state of atovaquone-proguanil (Atoguanil™) versus atovaquone-proguanil hydrochloride (Malarone®) in healthy adult participants. |
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| Authors: | Kuemmerle A; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland., Gossen D; Mangareva SRL, Kraainem, Belgium., Marx MW; ICON Clinical Research Germany GmbH, Langen, Germany., Lorch U; Richmond Pharmacology Ltd, London, UK., Szramowska M; PharmaKinetic Ltd, Quorn, UK., Kumar A; IPCA Laboratories Limited, Mumbai, India., Singh D; IPCA Laboratories Limited, Mumbai, India., Singh S; IPCA Laboratories Limited, Mumbai, India., Ramachandruni H; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland., Thankachen B; IPCA Laboratories Limited, Mumbai, India., Kore S; IPCA Laboratories Limited, Mumbai, India., Gaaloul ME; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland., Borghini-Fuhrer I; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland., Chalon S; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland. chalons@mmv.org. |
| Source: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Dec; Vol. 397 (12), pp. 9823-9832. Date of Electronic Publication: 2024 Jun 25. |
| Publication Type: | Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-1912 |
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| DOI: | 10.1007/s00210-024-03245-x |
