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A randomized, open-label two-period crossover pilot study to evaluate the relative bioavailability in the fed state of atovaquone-proguanil (Atoguanil™) versus atovaquone-proguanil hydrochloride (Malarone®) in healthy adult participants.

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Title: A randomized, open-label two-period crossover pilot study to evaluate the relative bioavailability in the fed state of atovaquone-proguanil (Atoguanil™) versus atovaquone-proguanil hydrochloride (Malarone®) in healthy adult participants.
Authors: Kuemmerle A; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland., Gossen D; Mangareva SRL, Kraainem, Belgium., Marx MW; ICON Clinical Research Germany GmbH, Langen, Germany., Lorch U; Richmond Pharmacology Ltd, London, UK., Szramowska M; PharmaKinetic Ltd, Quorn, UK., Kumar A; IPCA Laboratories Limited, Mumbai, India., Singh D; IPCA Laboratories Limited, Mumbai, India., Singh S; IPCA Laboratories Limited, Mumbai, India., Ramachandruni H; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland., Thankachen B; IPCA Laboratories Limited, Mumbai, India., Kore S; IPCA Laboratories Limited, Mumbai, India., Gaaloul ME; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland., Borghini-Fuhrer I; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland., Chalon S; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland. chalons@mmv.org.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Dec; Vol. 397 (12), pp. 9823-9832. Date of Electronic Publication: 2024 Jun 25.
Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A randomized, open-label two-period crossover pilot study to evaluate the relative bioavailability in the fed state of atovaquone-proguanil (Atoguanil™) versus atovaquone-proguanil hydrochloride (Malarone®) in healthy adult participants.
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  Data: <searchLink fieldCode="AU" term="%22Kuemmerle+A%22">Kuemmerle A</searchLink>; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gossen+D%22">Gossen D</searchLink>; Mangareva SRL, Kraainem, Belgium.<br /><searchLink fieldCode="AU" term="%22Marx+MW%22">Marx MW</searchLink>; ICON Clinical Research Germany GmbH, Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Lorch+U%22">Lorch U</searchLink>; Richmond Pharmacology Ltd, London, UK.<br /><searchLink fieldCode="AU" term="%22Szramowska+M%22">Szramowska M</searchLink>; PharmaKinetic Ltd, Quorn, UK.<br /><searchLink fieldCode="AU" term="%22Kumar+A%22">Kumar A</searchLink>; IPCA Laboratories Limited, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Singh+D%22">Singh D</searchLink>; IPCA Laboratories Limited, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; IPCA Laboratories Limited, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Ramachandruni+H%22">Ramachandruni H</searchLink>; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Thankachen+B%22">Thankachen B</searchLink>; IPCA Laboratories Limited, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Kore+S%22">Kore S</searchLink>; IPCA Laboratories Limited, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Gaaloul+ME%22">Gaaloul ME</searchLink>; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Borghini-Fuhrer+I%22">Borghini-Fuhrer I</searchLink>; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chalon+S%22">Chalon S</searchLink>; Medicines for Malaria Venture, ICC - Block G, 3rd floor, 20, Route de Pré-Bois, PO Box 1826, 1215, Geneva, Switzerland. chalons@mmv.org.
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  Data: <searchLink fieldCode="JN" term="%220326264%22">Naunyn-Schmiedeberg's archives of pharmacology</searchLink> [Naunyn Schmiedebergs Arch Pharmacol] 2024 Dec; Vol. 397 (12), pp. 9823-9832. <i>Date of Electronic Publication: </i>2024 Jun 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0326264 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1912 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200281298%22">00281298 </searchLink><i>NLM ISO Abbreviation: </i>Naunyn Schmiedebergs Arch Pharmacol <i>Subsets: </i>MEDLINE
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              Text: 2024 Dec
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