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Epigenetic-based differentiation therapy for Acute Myeloid Leukemia.

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Title: Epigenetic-based differentiation therapy for Acute Myeloid Leukemia.
Authors: San José-Enériz E; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain., Gimenez-Camino N; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain., Rabal O; Small-Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain., Garate L; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain., Miranda E; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain., Gómez-Echarte N; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain., García F; ProteoRed-ISCIII, Unidad de Proteómica, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, 28029, Madrid, Spain., Charalampopoulou S; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Casanova 143, 08036, Barcelona, Spain., Sáez E; Small-Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain., Vilas-Zornoza A; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain., San Martín-Uriz P; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain., Valcárcel LV; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.; TECNUN, Universidad de Navarra, Manuel de Lardizábal 13, 20018, San Sebastián, Spain., Barrena N; TECNUN, Universidad de Navarra, Manuel de Lardizábal 13, 20018, San Sebastián, Spain., Alignani D; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain., Tamariz-Amador LE; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.; Departmento de Hematología, Clínica Universidad de Navarra, and CCUN, Universidad de Navarra, Avenida Pío XII 36, 31008, Pamplona, Spain., Pérez-Ruiz A; Biomedical Engineering Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, Avenida Pío XII 55, 31008, Pamplona, Spain., Hilscher S; Department of Enzymology, Charles Tanford Protein Center, Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, 06120, Halle, Germany.; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, 06120, Halle, Germany., Schutkowski M; Department of Enzymology, Charles Tanford Protein Center, Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, 06120, Halle, Germany.; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, 06120, Halle, Germany., Alfonso-Pierola A; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.; Departmento de Hematología, Clínica Universidad de Navarra, and CCUN, Universidad de Navarra, Avenida Pío XII 36, 31008, Pamplona, Spain., Martinez-Calle N; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.; Departmento de Hematología, Clínica Universidad de Navarra, and CCUN, Universidad de Navarra, Avenida Pío XII 36, 31008, Pamplona, Spain., Larrayoz MJ; CIMA LAB Diagnostics, Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain., Paiva B; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain., Calasanz MJ; CIMA LAB Diagnostics, Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain., Muñoz J; Biocruces Bizkaia Health Research Institute, Cruces Plaza, 48903, Barakaldo, Spain.; Ikerbasque, Basque Foundation for Science, Plaza Euskadi 5, 48009, Bilbao, Spain., Isasa M; ProteoRed-ISCIII, Unidad de Proteómica, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, 28029, Madrid, Spain., Martin-Subero JI; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Casanova 143, 08036, Barcelona, Spain.; Departamento de Fundamentos Clínicos, Universitat de Barcelona, Casanova 143, 08036, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig de Lluís Companys 23, 08010, Barcelona, Spain., Pineda-Lucena A; Small-Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain., Oyarzabal J; Small-Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain. julenoyarzabal@external.unav.es., Agirre X; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain. xaguirre@unav.es.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain. xaguirre@unav.es., Prósper F; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain. fprosper@unav.es.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain. fprosper@unav.es.; Departmento de Hematología, Clínica Universidad de Navarra, and CCUN, Universidad de Navarra, Avenida Pío XII 36, 31008, Pamplona, Spain. fprosper@unav.es.
Source: Nature communications [Nat Commun] 2024 Jul 02; Vol. 15 (1), pp. 5570. Date of Electronic Publication: 2024 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Epigenetic-based differentiation therapy for Acute Myeloid Leukemia.
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  Data: <searchLink fieldCode="AU" term="%22San+José-Enériz+E%22">San José-Enériz E</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gimenez-Camino+N%22">Gimenez-Camino N</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rabal+O%22">Rabal O</searchLink>; Small-Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Garate+L%22">Garate L</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Miranda+E%22">Miranda E</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez-Echarte+N%22">Gómez-Echarte N</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22García+F%22">García F</searchLink>; ProteoRed-ISCIII, Unidad de Proteómica, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Charalampopoulou+S%22">Charalampopoulou S</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Casanova 143, 08036, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sáez+E%22">Sáez E</searchLink>; Small-Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Vilas-Zornoza+A%22">Vilas-Zornoza A</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22San+Martín-Uriz+P%22">San Martín-Uriz P</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Valcárcel+LV%22">Valcárcel LV</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.; TECNUN, Universidad de Navarra, Manuel de Lardizábal 13, 20018, San Sebastián, Spain.<br /><searchLink fieldCode="AU" term="%22Barrena+N%22">Barrena N</searchLink>; TECNUN, Universidad de Navarra, Manuel de Lardizábal 13, 20018, San Sebastián, Spain.<br /><searchLink fieldCode="AU" term="%22Alignani+D%22">Alignani D</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Tamariz-Amador+LE%22">Tamariz-Amador LE</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.; Departmento de Hematología, Clínica Universidad de Navarra, and CCUN, Universidad de Navarra, Avenida Pío XII 36, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez-Ruiz+A%22">Pérez-Ruiz A</searchLink>; Biomedical Engineering Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, Avenida Pío XII 55, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Hilscher+S%22">Hilscher S</searchLink>; Department of Enzymology, Charles Tanford Protein Center, Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, 06120, Halle, Germany.; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, 06120, Halle, Germany.<br /><searchLink fieldCode="AU" term="%22Schutkowski+M%22">Schutkowski M</searchLink>; Department of Enzymology, Charles Tanford Protein Center, Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, 06120, Halle, Germany.; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, 06120, Halle, Germany.<br /><searchLink fieldCode="AU" term="%22Alfonso-Pierola+A%22">Alfonso-Pierola A</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.; Departmento de Hematología, Clínica Universidad de Navarra, and CCUN, Universidad de Navarra, Avenida Pío XII 36, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez-Calle+N%22">Martinez-Calle N</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.; Departmento de Hematología, Clínica Universidad de Navarra, and CCUN, Universidad de Navarra, Avenida Pío XII 36, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Larrayoz+MJ%22">Larrayoz MJ</searchLink>; CIMA LAB Diagnostics, Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Paiva+B%22">Paiva B</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Calasanz+MJ%22">Calasanz MJ</searchLink>; CIMA LAB Diagnostics, Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Muñoz+J%22">Muñoz J</searchLink>; Biocruces Bizkaia Health Research Institute, Cruces Plaza, 48903, Barakaldo, Spain.; Ikerbasque, Basque Foundation for Science, Plaza Euskadi 5, 48009, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Isasa+M%22">Isasa M</searchLink>; ProteoRed-ISCIII, Unidad de Proteómica, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martin-Subero+JI%22">Martin-Subero JI</searchLink>; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Casanova 143, 08036, Barcelona, Spain.; Departamento de Fundamentos Clínicos, Universitat de Barcelona, Casanova 143, 08036, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig de Lluís Companys 23, 08010, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pineda-Lucena+A%22">Pineda-Lucena A</searchLink>; Small-Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Oyarzabal+J%22">Oyarzabal J</searchLink>; Small-Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, Avenida Pío XII 55, 31008, Pamplona, Spain. julenoyarzabal@external.unav.es.<br /><searchLink fieldCode="AU" term="%22Agirre+X%22">Agirre X</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain. xaguirre@unav.es.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain. xaguirre@unav.es.<br /><searchLink fieldCode="AU" term="%22Prósper+F%22">Prósper F</searchLink>; Hemato-Oncology Program, Center for Applied Medical Research (CIMA), Universidad de Navarra, IDISNA, CCUN, Avenida Pío XII 55, 31008, Pamplona, Spain. fprosper@unav.es.; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain. fprosper@unav.es.; Departmento de Hematología, Clínica Universidad de Navarra, and CCUN, Universidad de Navarra, Avenida Pío XII 36, 31008, Pamplona, Spain. fprosper@unav.es.
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