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Benefits for children with suspected cancer from routine whole-genome sequencing.

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Title: Benefits for children with suspected cancer from routine whole-genome sequencing.
Authors: Hodder A; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Leiter SM; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Kennedy J; Great Ormond Street Hospital NHS Foundation Trust, London, UK.; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Addy D; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Ahmed M; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Ajithkumar T; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Allinson K; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Ancliff P; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Bailey S; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Barnard G; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Burke GAA; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Burns C; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Cano-Flanagan J; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Chalker J; North Thames Genomic Laboratory Hub, London, UK., Coleman N; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Pathology, University of Cambridge, Cambridge, UK., Cheng D; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Clinch Y; North Thames Genomic Laboratory Hub, London, UK., Dryden C; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Ghorashian S; Great Ormond Street Hospital NHS Foundation Trust, London, UK.; UCL Great Ormond Street Institute of Child Health, London, UK., Griffin B; Great Ormond Street Hospital NHS Foundation Trust, London, UK.; North Thames Genomic Laboratory Hub, London, UK., Horan G; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Hubank M; North Thames Genomic Laboratory Hub, London, UK.; The Institute of Cancer Research, London, UK., May P; Great Ormond Street Hospital NHS Foundation Trust, London, UK., McDerra J; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Nagrecha R; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Nicholson J; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., O'Connor D; Great Ormond Street Hospital NHS Foundation Trust, London, UK.; UCL Cancer Institute, University College London, London, UK., Pavasovic V; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Quaegebeur A; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Rao A; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Roberts T; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; East Genomics Laboratory Hub, Cambridge, UK., Samarasinghe S; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Stasevich I; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Tadross JA; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; East Genomics Laboratory Hub, Cambridge, UK.; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Trayers C; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Trotman J; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; East Genomics Laboratory Hub, Cambridge, UK., Vora A; Great Ormond Street Hospital NHS Foundation Trust, London, UK., Watkins J; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Pathology, University of Cambridge, Cambridge, UK.; East Genomics Laboratory Hub, Cambridge, UK., Chitty LS; Great Ormond Street Hospital NHS Foundation Trust, London, UK.; North Thames Genomic Laboratory Hub, London, UK.; UCL Great Ormond Street Institute of Child Health, London, UK., Bowdin S; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; East Genomics Laboratory Hub, Cambridge, UK., Armstrong R; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Murray MJ; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. mjm16@cam.ac.uk.; Department of Pathology, University of Cambridge, Cambridge, UK. mjm16@cam.ac.uk., Hook CE; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. lizhook@nhs.net.; Department of Pathology, University of Cambridge, Cambridge, UK. lizhook@nhs.net., Tarpey P; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. patrick.tarpey1@nhs.net.; East Genomics Laboratory Hub, Cambridge, UK. patrick.tarpey1@nhs.net., Vedi A; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. a.vedi@nhs.net.; Department of Paediatrics, University of Cambridge, Cambridge, UK. a.vedi@nhs.net., Bartram J; Great Ormond Street Hospital NHS Foundation Trust, London, UK. jack.bartram@gosh.nhs.uk.; North Thames Genomic Laboratory Hub, London, UK. jack.bartram@gosh.nhs.uk., Behjati S; Wellcome Sanger Institute, Hinxton, UK. sb31@sanger.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. sb31@sanger.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, UK. sb31@sanger.ac.uk.
Source: Nature medicine [Nat Med] 2024 Jul; Vol. 30 (7), pp. 1905-1912. Date of Electronic Publication: 2024 Jul 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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