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Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs.

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Title: Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs.
Authors: Keuss MJ; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK., Harley P; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK., Ryadnov E; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK., Jackson RE; Centre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London; London SE1 1UL, UK., Zanovello M; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK., Wilkins OG; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.; The Francis Crick Institute; London, NW1 1AT, UK., Barattucci S; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK., Mehta PR; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK., Oliveira MG; Centre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London; London SE1 1UL, UK., Parkes JE; Nucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK., Sinha A; Nucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK., Correa-Sánchez AF; Nucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK., Oliver PL; Nucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK., Fisher EMC; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK., Schiavo G; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.; UK Dementia Research Institute at University College London; London, WC1N 3BG, UK., Shah M; Department of Pharmacology, School of Pharmacy, University College London; London, WC1N 4AX, UK., Burrone J; Centre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London; London SE1 1UL, UK., Fratta P; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.; The Francis Crick Institute; London, NW1 1AT, UK.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 24. Date of Electronic Publication: 2024 Jun 24.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs.
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  Data: <searchLink fieldCode="AU" term="%22Keuss+MJ%22">Keuss MJ</searchLink>; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Harley+P%22">Harley P</searchLink>; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Ryadnov+E%22">Ryadnov E</searchLink>; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Jackson+RE%22">Jackson RE</searchLink>; Centre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London; London SE1 1UL, UK.<br /><searchLink fieldCode="AU" term="%22Zanovello+M%22">Zanovello M</searchLink>; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Wilkins+OG%22">Wilkins OG</searchLink>; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.; The Francis Crick Institute; London, NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Barattucci+S%22">Barattucci S</searchLink>; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Mehta+PR%22">Mehta PR</searchLink>; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Oliveira+MG%22">Oliveira MG</searchLink>; Centre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London; London SE1 1UL, UK.<br /><searchLink fieldCode="AU" term="%22Parkes+JE%22">Parkes JE</searchLink>; Nucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK.<br /><searchLink fieldCode="AU" term="%22Sinha+A%22">Sinha A</searchLink>; Nucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK.<br /><searchLink fieldCode="AU" term="%22Correa-Sánchez+AF%22">Correa-Sánchez AF</searchLink>; Nucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK.<br /><searchLink fieldCode="AU" term="%22Oliver+PL%22">Oliver PL</searchLink>; Nucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK.<br /><searchLink fieldCode="AU" term="%22Fisher+EMC%22">Fisher EMC</searchLink>; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Schiavo+G%22">Schiavo G</searchLink>; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.; UK Dementia Research Institute at University College London; London, WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Shah+M%22">Shah M</searchLink>; Department of Pharmacology, School of Pharmacy, University College London; London, WC1N 4AX, UK.<br /><searchLink fieldCode="AU" term="%22Burrone+J%22">Burrone J</searchLink>; Centre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London; London SE1 1UL, UK.<br /><searchLink fieldCode="AU" term="%22Fratta+P%22">Fratta P</searchLink>; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.; The Francis Crick Institute; London, NW1 1AT, UK.
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