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Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency.

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Title: Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency.
Authors: Zakas PM; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Cunningham SC; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, NSW 2145, Australia., Doherty A; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., van Dijk EB; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, NSW 2145, Australia., Ibraheim R; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Yu S; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Mekonnen BD; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Lang B; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., English EJ; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Sun G; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Duncan MC; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Benczkowski MS; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Altshuler RC; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Singh MJ; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Kibbler ES; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Tonga GY; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Wang ZJ; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Wang ZJ; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Li G; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., An D; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Rottman JB; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Bhavsar Y; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Purcell C; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Jain R; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Alberry R; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Roquet N; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Fu Y; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Citorik RJ; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Rubens JR; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Holmes MC; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Cotta-Ramusino C; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Querbes W; Tessera Therapeutics, Inc., Somerville, MA 02143, USA., Alexander IE; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, NSW 2145, Australia; Discipline of Child and Adolescent Health, University of Sydney, Westmead, NSW 2145, Australia. Electronic address: ian.alexander@health.nsw.gov.au., Salomon WE; Tessera Therapeutics, Inc., Somerville, MA 02143, USA. Electronic address: wsalomon@tesseratx.com.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Oct 02; Vol. 32 (10), pp. 3356-3371. Date of Electronic Publication: 2024 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency.
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  Data: <searchLink fieldCode="AU" term="%22Zakas+PM%22">Zakas PM</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Cunningham+SC%22">Cunningham SC</searchLink>; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, NSW 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Doherty+A%22">Doherty A</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22van+Dijk+EB%22">van Dijk EB</searchLink>; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, NSW 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Ibraheim+R%22">Ibraheim R</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Yu+S%22">Yu S</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Mekonnen+BD%22">Mekonnen BD</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Lang+B%22">Lang B</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22English+EJ%22">English EJ</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Sun+G%22">Sun G</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Duncan+MC%22">Duncan MC</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Benczkowski+MS%22">Benczkowski MS</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Altshuler+RC%22">Altshuler RC</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Singh+MJ%22">Singh MJ</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Kibbler+ES%22">Kibbler ES</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Tonga+GY%22">Tonga GY</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Wang+ZJ%22">Wang ZJ</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Wang+ZJ%22">Wang ZJ</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22An+D%22">An D</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Rottman+JB%22">Rottman JB</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Bhavsar+Y%22">Bhavsar Y</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Purcell+C%22">Purcell C</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Jain+R%22">Jain R</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Alberry+R%22">Alberry R</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Roquet+N%22">Roquet N</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Fu+Y%22">Fu Y</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Citorik+RJ%22">Citorik RJ</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Rubens+JR%22">Rubens JR</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Holmes+MC%22">Holmes MC</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Cotta-Ramusino+C%22">Cotta-Ramusino C</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Querbes+W%22">Querbes W</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA.<br /><searchLink fieldCode="AU" term="%22Alexander+IE%22">Alexander IE</searchLink>; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, NSW 2145, Australia; Discipline of Child and Adolescent Health, University of Sydney, Westmead, NSW 2145, Australia. Electronic address: ian.alexander@health.nsw.gov.au.<br /><searchLink fieldCode="AU" term="%22Salomon+WE%22">Salomon WE</searchLink>; Tessera Therapeutics, Inc., Somerville, MA 02143, USA. Electronic address: wsalomon@tesseratx.com.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2024 Oct 02; Vol. 32 (10), pp. 3356-3371. <i>Date of Electronic Publication: </i>2024 Jul 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
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