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IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β-mediated immune suppression and potentiate anti-tumor responses in glioblastoma.

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Title: IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β-mediated immune suppression and potentiate anti-tumor responses in glioblastoma.
Authors: Hou AJ; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, USA., Shih RM; Department of Molecular Biology, University of California, Los Angeles, California, USA., Uy BR; Department of Neurosurgery, University of California, Los Angeles, California, USA., Shafer A; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA., Chang ZL; Department of Molecular Biology, University of California, Los Angeles, California, USA., Comin-Anduix B; Department of Surgery, University of California, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA., Guemes M; Department of Medicine, Division of Hematology/Oncology, University of California, Los Angeles, California, USA., Galic Z; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Department of Medicine, Division of Hematology/Oncology, University of California, Los Angeles, California, USA., Phyu S; Department of Neurosurgery, University of California, San Francisco, California, USA., Okada H; Department of Neurosurgery, University of California, San Francisco, California, USA.; Parker Institute for Cancer Immunotherapy Center at UCSF, San Francisco, California, USA., Grausam KB; Board of Governor's Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Breunig JJ; Board of Governor's Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Brown CE; Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, USA., Nathanson DA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA., Prins RM; Department of Neurosurgery, University of California, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA., Chen YY; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, USA.; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Parker Institute for Cancer Immunotherapy Center at UCLA, Los Angeles, California, USA.
Source: Neuro-oncology [Neuro Oncol] 2024 Oct 03; Vol. 26 (10), pp. 1850-1866.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β-mediated immune suppression and potentiate anti-tumor responses in glioblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Hou+AJ%22">Hou AJ</searchLink>; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Shih+RM%22">Shih RM</searchLink>; Department of Molecular Biology, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Uy+BR%22">Uy BR</searchLink>; Department of Neurosurgery, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Shafer+A%22">Shafer A</searchLink>; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Chang+ZL%22">Chang ZL</searchLink>; Department of Molecular Biology, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Comin-Anduix+B%22">Comin-Anduix B</searchLink>; Department of Surgery, University of California, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Guemes+M%22">Guemes M</searchLink>; Department of Medicine, Division of Hematology/Oncology, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Galic+Z%22">Galic Z</searchLink>; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Department of Medicine, Division of Hematology/Oncology, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Phyu+S%22">Phyu S</searchLink>; Department of Neurosurgery, University of California, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Okada+H%22">Okada H</searchLink>; Department of Neurosurgery, University of California, San Francisco, California, USA.; Parker Institute for Cancer Immunotherapy Center at UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Grausam+KB%22">Grausam KB</searchLink>; Board of Governor's Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Breunig+JJ%22">Breunig JJ</searchLink>; Board of Governor's Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Brown+CE%22">Brown CE</searchLink>; Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, USA.<br /><searchLink fieldCode="AU" term="%22Nathanson+DA%22">Nathanson DA</searchLink>; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Prins+RM%22">Prins RM</searchLink>; Department of Neurosurgery, University of California, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Chen+YY%22">Chen YY</searchLink>; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, USA.; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Parker Institute for Cancer Immunotherapy Center at UCLA, Los Angeles, California, USA.
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