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Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium.

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Title: Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium.
Authors: Eng JW; Division of Gastroenterology and Hepatology, Department of Medicine, College of Medicine, University of Illinois Chicago, Chicago, Illinois.; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois., Kato Y; Eisai Co., Ltd, Tsukuba, Japan., Adachi Y; Eisai Co., Ltd, Tsukuba, Japan., Swaminathan B; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois., Naiche LA; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois., Vadakath R; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois., Sakamoto Y; KAN Research Institute, Inc., Kobe, Japan., Nakazawa Y; Eisai Co., Ltd, Tsukuba, Japan., Tachino S; Eisai Co., Ltd, Tsukuba, Japan., Ito K; Eisai Co., Ltd, Tsukuba, Japan., Abe T; Eisai Co., Ltd, Tsukuba, Japan., Minoshima Y; Eisai Co., Ltd, Tsukuba, Japan., Hoshino-Negishi K; KAN Research Institute, Inc., Kobe, Japan., Ogasawara H; KAN Research Institute, Inc., Kobe, Japan., Kawakatsu T; KAN Research Institute, Inc., Kobe, Japan., Nishimura M; KAN Research Institute, Inc., Kobe, Japan., Katayama M; Eisai Co., Ltd, Tsukuba, Japan., Shimizu M; Eisai Co., Ltd, Tsukuba, Japan., Tahara K; Eisai Co., Ltd, Tsukuba, Japan., Sato T; Eisai Co., Ltd, Tsukuba, Japan., Suzuki K; Eisai Co., Ltd, Tsukuba, Japan., Agarwala K; Eisai Co., Ltd, Tsukuba, Japan., Iwata M; Eisai Co., Ltd, Tsukuba, Japan., Nomoto K; Eisai Inc., Woodcliff, New Jersey., Ozawa Y; Eisai Co., Ltd, Tsukuba, Japan., Imai T; KAN Research Institute, Inc., Kobe, Japan., Funahashi Y; Eisai Co., Ltd, Tsukuba, Japan., Matsui J; Eisai Inc., Woodcliff, New Jersey., Kitajewski J; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois.; University of Illinois Cancer Center, Chicago, Illinois.
Source: Cancer research communications [Cancer Res Commun] 2024 Jul 01; Vol. 4 (7), pp. 1881-1893.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium.
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  Data: <searchLink fieldCode="AU" term="%22Eng+JW%22">Eng JW</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine, College of Medicine, University of Illinois Chicago, Chicago, Illinois.; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Kato+Y%22">Kato Y</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Adachi+Y%22">Adachi Y</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Swaminathan+B%22">Swaminathan B</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Naiche+LA%22">Naiche LA</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Vadakath+R%22">Vadakath R</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Sakamoto+Y%22">Sakamoto Y</searchLink>; KAN Research Institute, Inc., Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Nakazawa+Y%22">Nakazawa Y</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Tachino+S%22">Tachino S</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+K%22">Ito K</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Abe+T%22">Abe T</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Minoshima+Y%22">Minoshima Y</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Hoshino-Negishi+K%22">Hoshino-Negishi K</searchLink>; KAN Research Institute, Inc., Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Ogasawara+H%22">Ogasawara H</searchLink>; KAN Research Institute, Inc., Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Kawakatsu+T%22">Kawakatsu T</searchLink>; KAN Research Institute, Inc., Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimura+M%22">Nishimura M</searchLink>; KAN Research Institute, Inc., Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Katayama+M%22">Katayama M</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+M%22">Shimizu M</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Tahara+K%22">Tahara K</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+T%22">Sato T</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Agarwala+K%22">Agarwala K</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Iwata+M%22">Iwata M</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Nomoto+K%22">Nomoto K</searchLink>; Eisai Inc., Woodcliff, New Jersey.<br /><searchLink fieldCode="AU" term="%22Ozawa+Y%22">Ozawa Y</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Imai+T%22">Imai T</searchLink>; KAN Research Institute, Inc., Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Funahashi+Y%22">Funahashi Y</searchLink>; Eisai Co., Ltd, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Matsui+J%22">Matsui J</searchLink>; Eisai Inc., Woodcliff, New Jersey.<br /><searchLink fieldCode="AU" term="%22Kitajewski+J%22">Kitajewski J</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois.; University of Illinois Cancer Center, Chicago, Illinois.
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  Data: <searchLink fieldCode="JN" term="%229918281580506676%22">Cancer research communications</searchLink> [Cancer Res Commun] 2024 Jul 01; Vol. 4 (7), pp. 1881-1893.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9918281580506676 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2767-9764 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227679764%22">27679764 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res Commun <i>Subsets: </i>MEDLINE
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