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Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer.

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Title: Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer.
Authors: Bagal SK; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Astles PC; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Diène C; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Argyrou A; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Crafter C; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Cassar DJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Fallan C; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Hock A; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Jones T; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Moreau K; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge CB4 0WG, U.K., Lamont GM; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Lamont S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Michaloglou C; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Packer MJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Pike A; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Ramos-Montoya A; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Scott JS; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Shaw J; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Shologu Z; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Jul 25; Vol. 67 (14), pp. 11732-11750. Date of Electronic Publication: 2024 Jul 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Bagal+SK%22">Bagal SK</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Astles+PC%22">Astles PC</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Diène+C%22">Diène C</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Argyrou+A%22">Argyrou A</searchLink>; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Crafter+C%22">Crafter C</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Cassar+DJ%22">Cassar DJ</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Fallan+C%22">Fallan C</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Hock+A%22">Hock A</searchLink>; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Jones+T%22">Jones T</searchLink>; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Moreau+K%22">Moreau K</searchLink>; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Lamont+GM%22">Lamont GM</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Lamont+S%22">Lamont S</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Michaloglou+C%22">Michaloglou C</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Packer+MJ%22">Packer MJ</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Pike+A%22">Pike A</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Ramos-Montoya+A%22">Ramos-Montoya A</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Scott+JS%22">Scott JS</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Shaw+J%22">Shaw J</searchLink>; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, U.K.<br /><searchLink fieldCode="AU" term="%22Shologu+Z%22">Shologu Z</searchLink>; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Jul 25; Vol. 67 (14), pp. 11732-11750. <i>Date of Electronic Publication: </i>2024 Jul 11.
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        Value: 10.1021/acs.jmedchem.4c00269
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        Text: English
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