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Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis: results of a randomized controlled trial.

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Title: Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis: results of a randomized controlled trial.
Authors: Rousel J; Centre for Human Drug Research, Leiden, The Netherlands; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Mergen C; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Bergmans ME; Centre for Human Drug Research, Leiden, The Netherlands; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands., Bruijnincx LJ; Centre for Human Drug Research, Leiden, The Netherlands., de Kam ML; Centre for Human Drug Research, Leiden, The Netherlands., Klarenbeek NB; Centre for Human Drug Research, Leiden, The Netherlands., Niemeyer-van der Kolk T; Centre for Human Drug Research, Leiden, The Netherlands., van Doorn MBA; Centre for Human Drug Research, Leiden, The Netherlands; Department of Dermatology, Erasmus Medical Centre, Rotterdam, The Netherlands., Bouwstra JA; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Rissmann R; Centre for Human Drug Research, Leiden, The Netherlands; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: rrissmann@chdr.nl.
Corporate Authors: Next-Generation ImmunoDermatology Consortium (NGID)
Source: Journal of lipid research [J Lipid Res] 2024 Aug; Vol. 65 (8), pp. 100591. Date of Electronic Publication: 2024 Jul 09.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis: results of a randomized controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Rousel+J%22">Rousel J</searchLink>; Centre for Human Drug Research, Leiden, The Netherlands; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mergen+C%22">Mergen C</searchLink>; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bergmans+ME%22">Bergmans ME</searchLink>; Centre for Human Drug Research, Leiden, The Netherlands; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bruijnincx+LJ%22">Bruijnincx LJ</searchLink>; Centre for Human Drug Research, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Kam+ML%22">de Kam ML</searchLink>; Centre for Human Drug Research, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Klarenbeek+NB%22">Klarenbeek NB</searchLink>; Centre for Human Drug Research, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Niemeyer-van+der+Kolk+T%22">Niemeyer-van der Kolk T</searchLink>; Centre for Human Drug Research, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Doorn+MBA%22">van Doorn MBA</searchLink>; Centre for Human Drug Research, Leiden, The Netherlands; Department of Dermatology, Erasmus Medical Centre, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bouwstra+JA%22">Bouwstra JA</searchLink>; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rissmann+R%22">Rissmann R</searchLink>; Centre for Human Drug Research, Leiden, The Netherlands; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: rrissmann@chdr.nl.
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  Data: <searchLink fieldCode="CA" term="%22Next-Generation+ImmunoDermatology+Consortium+%28NGID%29%22">Next-Generation ImmunoDermatology Consortium (NGID)</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220376606%22">Journal of lipid research</searchLink> [J Lipid Res] 2024 Aug; Vol. 65 (8), pp. 100591. <i>Date of Electronic Publication: </i>2024 Jul 09.
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  Data: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0376606 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1539-7262 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222275%22">00222275 </searchLink><i>NLM ISO Abbreviation: </i>J Lipid Res <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=38992724
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        Value: 10.1016/j.jlr.2024.100591
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      – Code: eng
        Text: English
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              M: 08
              Text: 2024 Aug
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