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Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471).

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Title: Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471).
Authors: Niessen J; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Nilsson JM; Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden., Peters K; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Indulkar A; AbbVie Research and Development, 1N Waukegan Road, North Chicago, IL, USA., Borchardt T; AbbVie Research and Development, 1N Waukegan Road, North Chicago, IL, USA., Koziolek M; Abbvie Deutschland GmbH & Co. KG, Small Molecule CMC Development, Knollstrasse, Ludwigshafen, Germany., Lennernäs H; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Dahlgren D; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Hedeland M; Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden. Electronic address: mikael.hedeland@ilk.uu.se.
Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2024 Oct 15; Vol. 249, pp. 116348. Date of Electronic Publication: 2024 Jul 09.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471).
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  Data: <searchLink fieldCode="AU" term="%22Niessen+J%22">Niessen J</searchLink>; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Nilsson+JM%22">Nilsson JM</searchLink>; Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Peters+K%22">Peters K</searchLink>; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Indulkar+A%22">Indulkar A</searchLink>; AbbVie Research and Development, 1N Waukegan Road, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Borchardt+T%22">Borchardt T</searchLink>; AbbVie Research and Development, 1N Waukegan Road, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Koziolek+M%22">Koziolek M</searchLink>; Abbvie Deutschland GmbH & Co. KG, Small Molecule CMC Development, Knollstrasse, Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Lennernäs+H%22">Lennernäs H</searchLink>; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Dahlgren+D%22">Dahlgren D</searchLink>; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Hedeland+M%22">Hedeland M</searchLink>; Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden. Electronic address: mikael.hedeland@ilk.uu.se.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8309336 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-264X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207317085%22">07317085 </searchLink><i>NLM ISO Abbreviation: </i>J Pharm Biomed Anal <i>Subsets: </i>MEDLINE
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