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Rational correction of pathogenic conformational defects in HTRA1.

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Title: Rational correction of pathogenic conformational defects in HTRA1.
Authors: Beaufort N; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Ingendahl L; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Merdanovic M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Schmidt A; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Graduate School of Systemic Neurosciences (GSN), LMU Munich, Munich, Germany., Podlesainski D; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Richter T; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Neumann T; Organic Chemistry, Faculty of Chemistry, University Duisburg-Essen, Essen, Germany., Kuszner M; Center of Medical Biotechnology, Faculty of Chemistry, University Duisburg-Essen, Essen, Germany., Vetter IR; Max-Planck-Institute of Molecular Physiology, Dortmund, Germany., Stege P; Max-Planck-Institute of Molecular Physiology, Dortmund, Germany., Burston SG; School of Biochemistry, University of Bristol, Biomedical Sciences Building, Bristol, UK., Filipovic A; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Ruiz-Blanco YB; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Bravo-Rodriguez K; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.; Max-Planck-Institute of Molecular Physiology, Dortmund, Germany., Mieres-Perez J; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.; Department of Biochemical and Chemical Engineering, Technical University Dortmund, Dortmund, Germany., Beuck C; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Uebel S; Max-Planck-Institute of Biochemistry, Martinsried, Germany., Zobawa M; Max-Planck-Institute of Biochemistry, Martinsried, Germany., Schillinger J; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Todorov-Völgyi K; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Rey J; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Roberti A; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Hagemeier B; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Wefers B; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute of Developmental Genetics (IDG), Helmholtz Zentrum München, Neuherberg, Germany., Müller SA; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Wurst W; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute of Developmental Genetics (IDG), Helmholtz Zentrum München, Neuherberg, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Technische Universität München-Weihenstephan, Freising, Germany., Sanchez-Garcia E; Department of Biochemical and Chemical Engineering, Technical University Dortmund, Dortmund, Germany., Zimmermann A; Center of Medical Biotechnology, Faculty of Chemistry, University Duisburg-Essen, Essen, Germany., Hu XY; College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, China., Clausen T; Research Institute of Molecular Pathology (IMP), Vienna, Austria., Huber R; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.; Max-Planck-Institute of Biochemistry, Martinsried, Germany., Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Schmuck C; Center of Medical Biotechnology, Faculty of Chemistry, University Duisburg-Essen, Essen, Germany., Giese M; Organic Chemistry, Faculty of Chemistry, University Duisburg-Essen, Essen, Germany., Kaiser M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Ehrmann M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany. Michael.Ehrmann@uni-due.de., Dichgans M; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany. dichgansmartin@gmail.com.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. dichgansmartin@gmail.com.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. dichgansmartin@gmail.com.
Source: Nature communications [Nat Commun] 2024 Jul 16; Vol. 15 (1), pp. 5944. Date of Electronic Publication: 2024 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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