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Understanding homologous recombination repair deficiency in biliary tract cancers: clinical implications and correlation with platinum sensitivity.

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Title: Understanding homologous recombination repair deficiency in biliary tract cancers: clinical implications and correlation with platinum sensitivity.
Authors: Mavroeidi IA; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany., Burghofer J; Laboratory for Molecular Genetic Diagnostics, Ordensklinikum Linz, Linz, Austria., Kalbourtzis S; Institute of Pathology, West German Cancer Center, University Hospital Essen, Essen, Germany., Taghizadeh H; Department of Internal Medicine, Universitätsklinikum St. Pölten, St. Pölten., Webersinke G; Laboratory for Molecular Genetic Diagnostics, Ordensklinikum Linz, Linz, Austria., Piringer G; Department of Oncology and Hematology, Kepler University Hospital, Linz; Medical Faculty, Johannes Kepler University Linz, Linz., Kasper S; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen., Schreil G; Department of Internal Medicine, State Hospital Pyhrn Eisenwurzen, Steyr., Liffers ST; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany., Reichinger A; Department of Internal Medicine I for Hematology with Stem Cell Transplantation, Hemostaseology, and Medical Oncology, Ordensklinikum Linz, Linz., Kirchweger P; Medical Faculty, Johannes Kepler University Linz, Linz; Department of General and Visceral Surgery, Ordensklinikum Linz, Linz; Gastrointestinal Cancer Center, Ordensklinikum Linz, Linz., Heibl S; Department of Internal Medicine IV, Hospital Wels-Grieskirchen, Wels, Austria., Hamacher R; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen., Schmitt CA; Department of Oncology and Hematology, Kepler University Hospital, Linz; Medical Faculty, Johannes Kepler University Linz, Linz., Schuler M; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; National Center for Tumor Diseases (NCT) West, Campus Essen, Essen, Germany., Prager GW; Department of Medicine I, Division of Oncology, Medical University Vienna, Vienna, Austria., Kersting D; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; Department of Nuclear Medicine, University Hospital Essen, Essen., Treckmann J; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen., Schildhaus HU; Institute of Pathology, West German Cancer Center, University Hospital Essen, Essen, Germany; Discovery Life Sciences Biomarker GmbH und Pathologie Nordhessen, Kassel, Germany., Rumpold H; Medical Faculty, Johannes Kepler University Linz, Linz; Gastrointestinal Cancer Center, Ordensklinikum Linz, Linz., Siveke JT; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany. Electronic address: jens.siveke@uk-essen.de., Doleschal B; Medical Faculty, Johannes Kepler University Linz, Linz; Department of Internal Medicine I for Hematology with Stem Cell Transplantation, Hemostaseology, and Medical Oncology, Ordensklinikum Linz, Linz. Electronic address: bernhard.doleschal@ordensklinikum.at.
Source: ESMO open [ESMO Open] 2024 Aug; Vol. 9 (8), pp. 103630. Date of Electronic Publication: 2024 Jul 16.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Understanding homologous recombination repair deficiency in biliary tract cancers: clinical implications and correlation with platinum sensitivity.
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  Data: <searchLink fieldCode="AU" term="%22Mavroeidi+IA%22">Mavroeidi IA</searchLink>; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Burghofer+J%22">Burghofer J</searchLink>; Laboratory for Molecular Genetic Diagnostics, Ordensklinikum Linz, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Kalbourtzis+S%22">Kalbourtzis S</searchLink>; Institute of Pathology, West German Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Taghizadeh+H%22">Taghizadeh H</searchLink>; Department of Internal Medicine, Universitätsklinikum St. Pölten, St. Pölten.<br /><searchLink fieldCode="AU" term="%22Webersinke+G%22">Webersinke G</searchLink>; Laboratory for Molecular Genetic Diagnostics, Ordensklinikum Linz, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Piringer+G%22">Piringer G</searchLink>; Department of Oncology and Hematology, Kepler University Hospital, Linz; Medical Faculty, Johannes Kepler University Linz, Linz.<br /><searchLink fieldCode="AU" term="%22Kasper+S%22">Kasper S</searchLink>; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen.<br /><searchLink fieldCode="AU" term="%22Schreil+G%22">Schreil G</searchLink>; Department of Internal Medicine, State Hospital Pyhrn Eisenwurzen, Steyr.<br /><searchLink fieldCode="AU" term="%22Liffers+ST%22">Liffers ST</searchLink>; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Reichinger+A%22">Reichinger A</searchLink>; Department of Internal Medicine I for Hematology with Stem Cell Transplantation, Hemostaseology, and Medical Oncology, Ordensklinikum Linz, Linz.<br /><searchLink fieldCode="AU" term="%22Kirchweger+P%22">Kirchweger P</searchLink>; Medical Faculty, Johannes Kepler University Linz, Linz; Department of General and Visceral Surgery, Ordensklinikum Linz, Linz; Gastrointestinal Cancer Center, Ordensklinikum Linz, Linz.<br /><searchLink fieldCode="AU" term="%22Heibl+S%22">Heibl S</searchLink>; Department of Internal Medicine IV, Hospital Wels-Grieskirchen, Wels, Austria.<br /><searchLink fieldCode="AU" term="%22Hamacher+R%22">Hamacher R</searchLink>; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen.<br /><searchLink fieldCode="AU" term="%22Schmitt+CA%22">Schmitt CA</searchLink>; Department of Oncology and Hematology, Kepler University Hospital, Linz; Medical Faculty, Johannes Kepler University Linz, Linz.<br /><searchLink fieldCode="AU" term="%22Schuler+M%22">Schuler M</searchLink>; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; National Center for Tumor Diseases (NCT) West, Campus Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Prager+GW%22">Prager GW</searchLink>; Department of Medicine I, Division of Oncology, Medical University Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kersting+D%22">Kersting D</searchLink>; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; Department of Nuclear Medicine, University Hospital Essen, Essen.<br /><searchLink fieldCode="AU" term="%22Treckmann+J%22">Treckmann J</searchLink>; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen.<br /><searchLink fieldCode="AU" term="%22Schildhaus+HU%22">Schildhaus HU</searchLink>; Institute of Pathology, West German Cancer Center, University Hospital Essen, Essen, Germany; Discovery Life Sciences Biomarker GmbH und Pathologie Nordhessen, Kassel, Germany.<br /><searchLink fieldCode="AU" term="%22Rumpold+H%22">Rumpold H</searchLink>; Medical Faculty, Johannes Kepler University Linz, Linz; Gastrointestinal Cancer Center, Ordensklinikum Linz, Linz.<br /><searchLink fieldCode="AU" term="%22Siveke+JT%22">Siveke JT</searchLink>; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany. Electronic address: jens.siveke@uk-essen.de.<br /><searchLink fieldCode="AU" term="%22Doleschal+B%22">Doleschal B</searchLink>; Medical Faculty, Johannes Kepler University Linz, Linz; Department of Internal Medicine I for Hematology with Stem Cell Transplantation, Hemostaseology, and Medical Oncology, Ordensklinikum Linz, Linz. Electronic address: bernhard.doleschal@ordensklinikum.at.
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  Data: <searchLink fieldCode="JN" term="%22101690685%22">ESMO open</searchLink> [ESMO Open] 2024 Aug; Vol. 9 (8), pp. 103630. <i>Date of Electronic Publication: </i>2024 Jul 16.
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