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KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults.

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Title: KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults.
Authors: Driscoll IF; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Lose S; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Ma Y; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Bendlin BB; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.; Geriatric Research Education and Clinical Center, William S. Middleton VA Hospital, Madison, Wisconsin, USA., Gallagher C; Geriatric Research Education and Clinical Center, William S. Middleton VA Hospital, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Johnson SC; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA., Asthana S; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.; Geriatric Research Education and Clinical Center, William S. Middleton VA Hospital, Madison, Wisconsin, USA., Hermann B; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Sager MA; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Göteborg, Sweden.; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, PR China., Zetterberg H; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Göteborg, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, PR China., Carlsson C; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.; Geriatric Research Education and Clinical Center, William S. Middleton VA Hospital, Madison, Wisconsin, USA., Kollmorgen G; Roche Diagnostics GmbH, Penzberg, Germany., Quijano-Rubio C; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Dubal D; Department of Neurology and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA., Okonkwo OC; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.; Geriatric Research Education and Clinical Center, William S. Middleton VA Hospital, Madison, Wisconsin, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Aug; Vol. 20 (8), pp. 5347-5356. Date of Electronic Publication: 2024 Jun 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults.
– Name: Author
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  Data: <searchLink fieldCode="AU" term="%22Driscoll+IF%22">Driscoll IF</searchLink>; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Lose+S%22">Lose S</searchLink>; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Bendlin+BB%22">Bendlin BB</searchLink>; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.; Geriatric Research Education and Clinical Center, William S. Middleton VA Hospital, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Gallagher+C%22">Gallagher C</searchLink>; Geriatric Research Education and Clinical Center, William S. Middleton VA Hospital, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+SC%22">Johnson SC</searchLink>; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Asthana+S%22">Asthana S</searchLink>; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.; Geriatric Research Education and Clinical Center, William S. Middleton VA Hospital, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Hermann+B%22">Hermann B</searchLink>; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Sager+MA%22">Sager MA</searchLink>; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Göteborg, Sweden.; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, PR China.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Göteborg, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, PR China.<br /><searchLink fieldCode="AU" term="%22Carlsson+C%22">Carlsson C</searchLink>; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.; Geriatric Research Education and Clinical Center, William S. Middleton VA Hospital, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Kollmorgen+G%22">Kollmorgen G</searchLink>; Roche Diagnostics GmbH, Penzberg, Germany.<br /><searchLink fieldCode="AU" term="%22Quijano-Rubio+C%22">Quijano-Rubio C</searchLink>; Roche Diagnostics International Ltd, Rotkreuz, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dubal+D%22">Dubal D</searchLink>; Department of Neurology and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Okonkwo+OC%22">Okonkwo OC</searchLink>; Wisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, Madison, Wisconsin, USA.; Geriatric Research Education and Clinical Center, William S. Middleton VA Hospital, Madison, Wisconsin, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2024 Aug; Vol. 20 (8), pp. 5347-5356. <i>Date of Electronic Publication: </i>2024 Jun 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39030746
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        Value: 10.1002/alz.13912
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