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Rapid protein evolution by few-shot learning with a protein language model.

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Title: Rapid protein evolution by few-shot learning with a protein language model.
Authors: Jiang K; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA.; Department of Bioengineering Massachusetts Institute of Technology Cambridge, 02139 MA, USA., Yan Z; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA., Di Bernardo M; Department of Bioengineering Massachusetts Institute of Technology Cambridge, 02139 MA, USA., Sgrizzi SR; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA., Villiger L; Department of Dermatology and Allergology Kantonspital St. Gallen St. Gallen, 9000, Switzerland., Kayabolen A; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA., Kim B; Koch Institute for Integrative Cancer Research At MIT Massachusetts Institute of Technology Cambridge, 02139 MA, USA., Carscadden JK; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA., Hiraizumi M; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan., Nishimasu H; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.; Structural Biology Division, Research Center for Advanced Science and Technology, The University of Tokyo 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.; Inamori Research Institute for Science 620 Suiginya-cho, Shimogyo-ku, Kyoto 600-8411, Japan., Gootenberg JS; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA., Abudayyeh OO; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 18. Date of Electronic Publication: 2024 Jul 18.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Rapid protein evolution by few-shot learning with a protein language model.
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  Data: <searchLink fieldCode="AU" term="%22Jiang+K%22">Jiang K</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA.; Department of Bioengineering Massachusetts Institute of Technology Cambridge, 02139 MA, USA.<br /><searchLink fieldCode="AU" term="%22Yan+Z%22">Yan Z</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA.<br /><searchLink fieldCode="AU" term="%22Di+Bernardo+M%22">Di Bernardo M</searchLink>; Department of Bioengineering Massachusetts Institute of Technology Cambridge, 02139 MA, USA.<br /><searchLink fieldCode="AU" term="%22Sgrizzi+SR%22">Sgrizzi SR</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA.<br /><searchLink fieldCode="AU" term="%22Villiger+L%22">Villiger L</searchLink>; Department of Dermatology and Allergology Kantonspital St. Gallen St. Gallen, 9000, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kayabolen+A%22">Kayabolen A</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+B%22">Kim B</searchLink>; Koch Institute for Integrative Cancer Research At MIT Massachusetts Institute of Technology Cambridge, 02139 MA, USA.<br /><searchLink fieldCode="AU" term="%22Carscadden+JK%22">Carscadden JK</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA.<br /><searchLink fieldCode="AU" term="%22Hiraizumi+M%22">Hiraizumi M</searchLink>; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimasu+H%22">Nishimasu H</searchLink>; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.; Structural Biology Division, Research Center for Advanced Science and Technology, The University of Tokyo 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.; Inamori Research Institute for Science 620 Suiginya-cho, Shimogyo-ku, Kyoto 600-8411, Japan.<br /><searchLink fieldCode="AU" term="%22Gootenberg+JS%22">Gootenberg JS</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA.<br /><searchLink fieldCode="AU" term="%22Abudayyeh+OO%22">Abudayyeh OO</searchLink>; Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School Boston, 02115 MA, USA.; Gene and Cell Therapy Institute Mass General Brigham Cambridge, 02139 MA, USA.; Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School Boston, 02115 MA, USA.
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      – Type: doi
        Value: 10.1101/2024.07.17.604015
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        Text: English
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      – TitleFull: Rapid protein evolution by few-shot learning with a protein language model.
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              Text: 2024 Jul 18
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