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Structure-based design, synthesis, and biological characterization of indolylarylsulfone derivatives as novel human immunodeficiency virus type 1 inhibitors with potent antiviral activities and favorable drug-like profiles.

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Title: Structure-based design, synthesis, and biological characterization of indolylarylsulfone derivatives as novel human immunodeficiency virus type 1 inhibitors with potent antiviral activities and favorable drug-like profiles.
Authors: Wang Z; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Jinan, Shandong, China.; Suzhou Research Institute of Shandong University, Suzhou, Jiangsu, China., Wang W; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China., Gao Z; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China., Gao H; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China., Clercq E; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium., Pannecouque C; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium., Chen CH; Surgical Oncology Research Facility, Duke University Medical Center, Durham, North Carolina, USA., Kang D; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Jinan, Shandong, China., Zhan P; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Jinan, Shandong, China., Liu X; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Jinan, Shandong, China.
Source: Journal of medical virology [J Med Virol] 2024 Aug; Vol. 96 (8), pp. e29830.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structure-based design, synthesis, and biological characterization of indolylarylsulfone derivatives as novel human immunodeficiency virus type 1 inhibitors with potent antiviral activities and favorable drug-like profiles.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Jinan, Shandong, China.; Suzhou Research Institute of Shandong University, Suzhou, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Gao+Z%22">Gao Z</searchLink>; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Gao+H%22">Gao H</searchLink>; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Clercq+E%22">Clercq E</searchLink>; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Pannecouque+C%22">Pannecouque C</searchLink>; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Surgical Oncology Research Facility, Duke University Medical Center, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Kang+D%22">Kang D</searchLink>; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhan+P%22">Zhan P</searchLink>; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Jinan, Shandong, China.
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              Text: 2024 Aug
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