Genomic Discovery and Structure-Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors.
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| Title: | Genomic Discovery and Structure-Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors. |
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| Authors: | Davison JR; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Hadjithomas M; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Romeril SP; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Choi YJ; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Bentley KW; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Biggins JB; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Chacko N; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Castaldi MP; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Chan LK; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Cumming JN; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Downes TD; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Eisenhauer EL; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Fei F; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Fontaine BM; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Endalur Gopinarayanan V; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Gurnani S; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Hecht A; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Hosford CJ; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Ibrahim A; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Jagels A; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Joubran C; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Kim JN; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Lisher JP; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Liu DD; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Lyles JT; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Mannara MN; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Murray GJ; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Musial E; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Niu M; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Olivares-Amaya R; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Percuoco M; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Saalau S; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Sharpe K; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Sheahan AV; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Thevakumaran N; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Thompson JE; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Thompson DA; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Wiest A; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Wyka SA; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Yano J; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States., Verdine GL; LifeMine Therapeutics, 30 Acorn Park Drive, Cambridge, Massachusetts 02140, United States.; Departments of Chemistry and Chemical Biology, and Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, 12 Oxford Street, Cambridge, Massachusetts 02138, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2024 Aug 08; Vol. 67 (15), pp. 13147-13173. Date of Electronic Publication: 2024 Jul 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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