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In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells.

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Title: In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells.
Authors: Palanki R; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Riley JS; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Bose SK; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Luks V; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Dave A; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Kus N; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104., White BM; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Ricciardi AS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Swingle KL; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Xue L; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Sung D; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Thatte AS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Safford HC; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Chaluvadi VS; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Carpenter M; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Han EL; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Maganti R; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Hamilton AG; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Mrksich K; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Billingsley MB; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Zoltick PW; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Alameh MG; Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Weissman D; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Peranteau WH; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 06; Vol. 121 (32), pp. e2400783121. Date of Electronic Publication: 2024 Jul 30.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells.
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  Data: <searchLink fieldCode="AU" term="%22Palanki+R%22">Palanki R</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Riley+JS%22">Riley JS</searchLink>; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Bose+SK%22">Bose SK</searchLink>; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Luks+V%22">Luks V</searchLink>; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Dave+A%22">Dave A</searchLink>; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Kus+N%22">Kus N</searchLink>; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22White+BM%22">White BM</searchLink>; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Ricciardi+AS%22">Ricciardi AS</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Swingle+KL%22">Swingle KL</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Xue+L%22">Xue L</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Sung+D%22">Sung D</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Thatte+AS%22">Thatte AS</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Safford+HC%22">Safford HC</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Chaluvadi+VS%22">Chaluvadi VS</searchLink>; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Carpenter+M%22">Carpenter M</searchLink>; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Han+EL%22">Han EL</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Maganti+R%22">Maganti R</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Hamilton+AG%22">Hamilton AG</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Mrksich+K%22">Mrksich K</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Billingsley+MB%22">Billingsley MB</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Zoltick+PW%22">Zoltick PW</searchLink>; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Alameh+MG%22">Alameh MG</searchLink>; Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Weissman+D%22">Weissman D</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Mitchell+MJ%22">Mitchell MJ</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Peranteau+WH%22">Peranteau WH</searchLink>; Center for Fetal Research, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2024 Aug 06; Vol. 121 (32), pp. e2400783121. <i>Date of Electronic Publication: </i>2024 Jul 30.
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