View in EDS

JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans.

Saved in:
Bibliographic Details
Title: JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans.
Authors: Fourie AM; Janssen Research & Development, LLC, La Jolla, CA, USA. afourie@its.jnj.com., Cheng X; Protagonist Therapeutics, Newark, CA, USA., Chang L; Janssen Research & Development, LLC, La Jolla, CA, USA., Greving C; Janssen Research & Development, LLC, La Jolla, CA, USA., Li X; Janssen Research & Development, LLC, La Jolla, CA, USA., Knight B; Janssen Research & Development, LLC, La Jolla, CA, USA., Polidori D; Janssen Research & Development, LLC, La Jolla, CA, USA., Patrick A; Janssen Research & Development, LLC, Spring House, PA, USA., Bains T; Janssen Research & Development, LLC, Spring House, PA, USA., Steele R; Janssen Research & Development, LLC, Spring House, PA, USA., Allen SJ; Janssen Research & Development, LLC, Spring House, PA, USA., Patch RJ; Janssen Research & Development, LLC, Spring House, PA, USA., Sun C; Janssen Research & Development, LLC, Spring House, PA, USA., Somani S; Janssen Research & Development, LLC, Spring House, PA, USA., Bhandari A; Protagonist Therapeutics, Newark, CA, USA., Liu D; Protagonist Therapeutics, Newark, CA, USA., Huie K; Protagonist Therapeutics, Newark, CA, USA., Li S; Protagonist Therapeutics, Newark, CA, USA., Rodriguez MA; Janssen Research & Development, LLC, La Jolla, CA, USA., Xue X; Janssen Research & Development, LLC, La Jolla, CA, USA., Kannan A; Janssen Research & Development, LLC, La Jolla, CA, USA., Kosoglou T; Janssen Research & Development, LLC, Spring House, PA, USA., Sherlock JP; Janssen Research & Development, LLC, Spring House, PA, USA., Towne J; Janssen Research & Development, LLC, La Jolla, CA, USA., Holland MC; Janssen Research & Development, LLC, Spring House, PA, USA., Modi NB; Protagonist Therapeutics, Newark, CA, USA.
Source: Scientific reports [Sci Rep] 2024 Jul 30; Vol. 14 (1), pp. 17515. Date of Electronic Publication: 2024 Jul 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 39080319
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Fourie+AM%22">Fourie AM</searchLink>; Janssen Research & Development, LLC, La Jolla, CA, USA. afourie@its.jnj.com.<br /><searchLink fieldCode="AU" term="%22Cheng+X%22">Cheng X</searchLink>; Protagonist Therapeutics, Newark, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+L%22">Chang L</searchLink>; Janssen Research & Development, LLC, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Greving+C%22">Greving C</searchLink>; Janssen Research & Development, LLC, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Janssen Research & Development, LLC, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Knight+B%22">Knight B</searchLink>; Janssen Research & Development, LLC, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Polidori+D%22">Polidori D</searchLink>; Janssen Research & Development, LLC, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Patrick+A%22">Patrick A</searchLink>; Janssen Research & Development, LLC, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bains+T%22">Bains T</searchLink>; Janssen Research & Development, LLC, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Steele+R%22">Steele R</searchLink>; Janssen Research & Development, LLC, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Allen+SJ%22">Allen SJ</searchLink>; Janssen Research & Development, LLC, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Patch+RJ%22">Patch RJ</searchLink>; Janssen Research & Development, LLC, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sun+C%22">Sun C</searchLink>; Janssen Research & Development, LLC, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Somani+S%22">Somani S</searchLink>; Janssen Research & Development, LLC, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bhandari+A%22">Bhandari A</searchLink>; Protagonist Therapeutics, Newark, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Protagonist Therapeutics, Newark, CA, USA.<br /><searchLink fieldCode="AU" term="%22Huie+K%22">Huie K</searchLink>; Protagonist Therapeutics, Newark, CA, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Protagonist Therapeutics, Newark, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+MA%22">Rodriguez MA</searchLink>; Janssen Research & Development, LLC, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xue+X%22">Xue X</searchLink>; Janssen Research & Development, LLC, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kannan+A%22">Kannan A</searchLink>; Janssen Research & Development, LLC, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kosoglou+T%22">Kosoglou T</searchLink>; Janssen Research & Development, LLC, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sherlock+JP%22">Sherlock JP</searchLink>; Janssen Research & Development, LLC, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Towne+J%22">Towne J</searchLink>; Janssen Research & Development, LLC, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Holland+MC%22">Holland MC</searchLink>; Janssen Research & Development, LLC, Spring House, PA, USA.<br /><searchLink fieldCode="AU" term="%22Modi+NB%22">Modi NB</searchLink>; Protagonist Therapeutics, Newark, CA, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2024 Jul 30; Vol. 14 (1), pp. 17515. <i>Date of Electronic Publication: </i>2024 Jul 30.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39080319
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41598-024-67371-5
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 17515
    Titles:
      – TitleFull: JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Fourie AM
      – PersonEntity:
          Name:
            NameFull: Cheng X
      – PersonEntity:
          Name:
            NameFull: Chang L
      – PersonEntity:
          Name:
            NameFull: Greving C
      – PersonEntity:
          Name:
            NameFull: Li X
      – PersonEntity:
          Name:
            NameFull: Knight B
      – PersonEntity:
          Name:
            NameFull: Polidori D
      – PersonEntity:
          Name:
            NameFull: Patrick A
      – PersonEntity:
          Name:
            NameFull: Bains T
      – PersonEntity:
          Name:
            NameFull: Steele R
      – PersonEntity:
          Name:
            NameFull: Allen SJ
      – PersonEntity:
          Name:
            NameFull: Patch RJ
      – PersonEntity:
          Name:
            NameFull: Sun C
      – PersonEntity:
          Name:
            NameFull: Somani S
      – PersonEntity:
          Name:
            NameFull: Bhandari A
      – PersonEntity:
          Name:
            NameFull: Liu D
      – PersonEntity:
          Name:
            NameFull: Huie K
      – PersonEntity:
          Name:
            NameFull: Li S
      – PersonEntity:
          Name:
            NameFull: Rodriguez MA
      – PersonEntity:
          Name:
            NameFull: Xue X
      – PersonEntity:
          Name:
            NameFull: Kannan A
      – PersonEntity:
          Name:
            NameFull: Kosoglou T
      – PersonEntity:
          Name:
            NameFull: Sherlock JP
      – PersonEntity:
          Name:
            NameFull: Towne J
      – PersonEntity:
          Name:
            NameFull: Holland MC
      – PersonEntity:
          Name:
            NameFull: Modi NB
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 30
              M: 07
              Text: 2024 Jul 30
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-electronic
              Value: 2045-2322
          Numbering:
            – Type: volume
              Value: 14
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Scientific reports
              Type: main
ResultId 1