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Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.

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Title: Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.
Authors: Bumpers QA; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Pipal RW; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Benz-Weeden AM; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Brewster JT 2nd; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Cook A; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Crooks AL; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Cruz C; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Dwulet NC; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Gaudino JJ; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Golec D; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Harrison JA; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Hartley DP; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Hassanien SH; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Hicken EJ; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Kahn D; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Laird ER; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Lemieux C; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Lewandowski N; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., McCown J; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., McDonald MG; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., McNulty O; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Mou TC; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Nguyen P; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Oko L; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Opie LP; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Otten J; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Peck SC; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Polites VC; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Randall SD; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Rosen RZ; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Savechenkov P; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Simpson H; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Singh A; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Sparks D; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Wickersham K; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Wollenberg L; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Wong CE; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Wong J; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Wu WI; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Elsayed MSA; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Hinklin RJ; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Tang TP; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14466-14477. Date of Electronic Publication: 2024 Aug 01.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.
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