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Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer's disease.

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Title: Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer's disease.
Authors: Jury-Garfe N; Stark Neurosciences Research Institute, Indiana University School of Medicine, Neurosciences Research Building 214G, 320 West 15th Street, Indianapolis, IN, 46202, USA.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA., Redding-Ochoa J; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA., You Y; Stark Neurosciences Research Institute, Indiana University School of Medicine, Neurosciences Research Building 214G, 320 West 15th Street, Indianapolis, IN, 46202, USA.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA., Martínez P; Stark Neurosciences Research Institute, Indiana University School of Medicine, Neurosciences Research Building 214G, 320 West 15th Street, Indianapolis, IN, 46202, USA.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA., Karahan H; Stark Neurosciences Research Institute, Indiana University School of Medicine, Neurosciences Research Building 214G, 320 West 15th Street, Indianapolis, IN, 46202, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA., Chimal-Juárez E; Stark Neurosciences Research Institute, Indiana University School of Medicine, Neurosciences Research Building 214G, 320 West 15th Street, Indianapolis, IN, 46202, USA.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA., Johnson TS; Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, USA., Zhang J; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA., Resnick S; Laboratory of Behavioral Neuroscience, National Institute on Aging and National Institute of Health, Baltimore, MD, USA., Kim J; Stark Neurosciences Research Institute, Indiana University School of Medicine, Neurosciences Research Building 214G, 320 West 15th Street, Indianapolis, IN, 46202, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA., Troncoso JC; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA., Lasagna-Reeves CA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Neurosciences Research Building 214G, 320 West 15th Street, Indianapolis, IN, 46202, USA. clasagna@iu.edu.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA. clasagna@iu.edu.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA. clasagna@iu.edu.
Source: Acta neuropathologica [Acta Neuropathol] 2024 Aug 05; Vol. 148 (1), pp. 15. Date of Electronic Publication: 2024 Aug 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Intramural
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer's disease.
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