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New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer.

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Title: New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer.
Authors: Espinosa-Bustos C; Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile., Bertrand J; Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile., Villegas-Menares A; Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile., Guerrero S; Facultad de Medicina, Universidad de Atacama, 153601 Copiapó, Chile., Di Marcotullio L; Department of Molecular Medicine, Faculty Pharmacy and Medicine, Sapienza University, 00161 Rome, Italy; Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University, 00161 Rome, Italy., Navacci S; Department of Molecular Medicine, Faculty Pharmacy and Medicine, Sapienza University, 00161 Rome, Italy., Schulte G; Department of Physiology and Pharmacology, Karolinska Institute, 17165 Solna, Stockholm, Sweden., Kozielewicz P; Department of Physiology and Pharmacology, Karolinska Institute, 17165 Solna, Stockholm, Sweden., Bloch N; Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile., Villela V; Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile., Paulino M; Departamento DETEMA, Facultad de Química, Universidad de la República, 11800 Montevideo, Uruguay., Kogan MJ; Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 8380492 Santiago, Chile; Advanced Center of Chronic Diseases (ACCDiS), Universidad de Chile, 8380492 Santiago, Chile., Cantero J; Departamento DETEMA, Facultad de Química, Universidad de la República, 11800 Montevideo, Uruguay., Salas CO; Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile. Electronic address: cosalas@uc.cl.
Source: Bioorganic chemistry [Bioorg Chem] 2024 Oct; Vol. 151, pp. 107681. Date of Electronic Publication: 2024 Jul 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Espinosa-Bustos+C%22">Espinosa-Bustos C</searchLink>; Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Bertrand+J%22">Bertrand J</searchLink>; Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Villegas-Menares+A%22">Villegas-Menares A</searchLink>; Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Guerrero+S%22">Guerrero S</searchLink>; Facultad de Medicina, Universidad de Atacama, 153601 Copiapó, Chile.<br /><searchLink fieldCode="AU" term="%22Di+Marcotullio+L%22">Di Marcotullio L</searchLink>; Department of Molecular Medicine, Faculty Pharmacy and Medicine, Sapienza University, 00161 Rome, Italy; Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Navacci+S%22">Navacci S</searchLink>; Department of Molecular Medicine, Faculty Pharmacy and Medicine, Sapienza University, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Schulte+G%22">Schulte G</searchLink>; Department of Physiology and Pharmacology, Karolinska Institute, 17165 Solna, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Kozielewicz+P%22">Kozielewicz P</searchLink>; Department of Physiology and Pharmacology, Karolinska Institute, 17165 Solna, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bloch+N%22">Bloch N</searchLink>; Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Villela+V%22">Villela V</searchLink>; Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Paulino+M%22">Paulino M</searchLink>; Departamento DETEMA, Facultad de Química, Universidad de la República, 11800 Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Kogan+MJ%22">Kogan MJ</searchLink>; Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 8380492 Santiago, Chile; Advanced Center of Chronic Diseases (ACCDiS), Universidad de Chile, 8380492 Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Cantero+J%22">Cantero J</searchLink>; Departamento DETEMA, Facultad de Química, Universidad de la República, 11800 Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Salas+CO%22">Salas CO</searchLink>; Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago, Chile. Electronic address: cosalas@uc.cl.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2024 Oct; Vol. 151, pp. 107681. <i>Date of Electronic Publication: </i>2024 Jul 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1303703 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2120 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200452068%22">00452068 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Chem <i>Subsets: </i>MEDLINE
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