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Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors.

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Title: Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors.
Authors: Saha PP; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Gogonea V; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Chemistry Department, Cleveland State University, 2121 Euclid Ave., Cleveland, OH, USA., Sweet W; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Mohan ML; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Singh KD; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Anderson JT; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Mallela D; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Witherow C; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Kar N; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Stenson K; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Harford T; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Fischbach MA; Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA, USA., Brown JM; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Karnik SS; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Moravec CS; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., DiDonato JA; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Naga Prasad SV; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA., Hazen SL; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA. hazens@ccf.org.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA. hazens@ccf.org.; Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA. hazens@ccf.org.
Source: Nature communications [Nat Commun] 2024 Aug 06; Vol. 15 (1), pp. 6696. Date of Electronic Publication: 2024 Aug 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Saha+PP%22">Saha PP</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Gogonea+V%22">Gogonea V</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Chemistry Department, Cleveland State University, 2121 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Sweet+W%22">Sweet W</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Mohan+ML%22">Mohan ML</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Singh+KD%22">Singh KD</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+JT%22">Anderson JT</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Mallela+D%22">Mallela D</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Witherow+C%22">Witherow C</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Kar+N%22">Kar N</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Stenson+K%22">Stenson K</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Harford+T%22">Harford T</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Fischbach+MA%22">Fischbach MA</searchLink>; Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Brown+JM%22">Brown JM</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Karnik+SS%22">Karnik SS</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Moravec+CS%22">Moravec CS</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22DiDonato+JA%22">DiDonato JA</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Naga+Prasad+SV%22">Naga Prasad SV</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hazen+SL%22">Hazen SL</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA. hazens@ccf.org.; Center for Microbiome & Human Health, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, USA. hazens@ccf.org.; Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA. hazens@ccf.org.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2024 Aug 06; Vol. 15 (1), pp. 6696. <i>Date of Electronic Publication: </i>2024 Aug 06.
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